Solvent-Mediated Polymorphic Transformation of Famoxadone from Form II to Form I in Several Mixed Solvent Systems

This paper discloses six polymorphs of famoxadone obtained from polymorph screening, which were characterized by XRPD, DSC, and SEM. A study of solvent-mediated polymorphic transformation (SMPT) of famoxadone from the metastable Form II to the stable Form I in several mixed solvent systems at the temperature of 30 °C was also conducted. The transformation process was monitored by Process Analytical Technologies. It was confirmed that the Form II to Form I polymorphic transformation is controlled by the Form I growth process. The transformation rate constants depended linearly on the solubility difference value between Form I and Form II. Furthermore, the hydrogen-bond-donation/acceptance ability and dipolar polarizability also had an effect on the rate of solvent-mediated polymorphic transformation.

Physical and Electrical Properties of Cullet-Paper Ash-Kaolin Clay Ceramic

A series of (x) paper ash- (80-x) cullet – 20 Kaolin clay where 10 ≤x≤30 weight % has successfully been prepared using solid state reaction method. The ceramic density and hardness has been determined using Archimedes and Vickers hardness method respectively. The dielectric constant and dielectric loss has been determined using impedance analyzer. The obtained density is descending from 2.18 gcm-3 to 1.90 gcm-3 and hardness is increased up to 871.8 Mpa. The decrement of density and hardness as the cullet content increases is due to the non uniform vitreous areas formed in between ceramic particle. The variation of the dielectric constant and dielectric loss tangent are found to decrease with increasing of frequency which suggest the dipolar polarizability properties. It is found that the maximum value of dielectric constant is 3000 and minimum dielectric loss tangent is 0.166.