oddi’s sphincter
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2020 ◽  
Vol 73 (1) ◽  
pp. 41-45
Author(s):  
Alexandr E. Abaturov ◽  
Iryna L. Vysochyna ◽  
Veronika L. Babych ◽  
Victor E. Dosenko

The alm: To study the effect of choleretic therapy on the level of microRNA expression in functional disorders of the gallbladder and Oddi’s sphincter in children. Materials and methods: Fifty patients with functional disorders of the gallbladder and Oddi’s sphincter who received standard therapy in combination with ursodeoxycholic acid, 20 patients – standard therapy without ursodeoxycholic acid, and 20 healthy children were examined. The level of expression of microRNA-378f, microRNA-4311, microRNA-4714-3p in the blood serum by the method of real-time polymerase chain reaction with reverse transcription according to the protocol TaqMan Gene Expression Assays was performed. Results: It was demonstrated that the activity profile of microRNA-4714-3p was significantly lower in those examined with functional disorders of the gallbladder and Oddi’s sphincter than in practically healthy children (p<0.05). After standard therapy combined with ursodeoxycholic acid in children with functional disorders of the gallbladder and Oddi’s sphincter, the level of expression of microRNA-378f is significantly higher than before therapy (5.23±0.70 SU and 2.02±0.57 SU respectively) (p<0.05). Against the background of standard therapy with the addition of ursodeoxycholic acid or without it, the expression profile of microRNA-4714-3p in the blood serum in children with functional disorders of the gallbladder and Oddi’s sphincter significantly decreased (1.93±0.58 SU and 1,14±0,53 SU respectively) (p<0.05). Conclusions: Ursodeoxycholic acid in children with functional disorders of the gallbladder and Oddi’s sphincter affects the activity of generation of gene regulators of the cellular mechanisms of microRNA-378f and microRNA-4714-3p.


2015 ◽  
Vol 0 (3.57) ◽  
pp. 34-39
Author(s):  
L.M. Mosiychuk ◽  
I.V. Kushnirenko ◽  
L.V. Demeshkina ◽  
I.O. Vasilieva ◽  
V.M. Yarosh ◽  
...  

Hepatology ◽  
1993 ◽  
Vol 17 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Mohammad Sultan Khuroo ◽  
Showkat Ali Zargar ◽  
Ghulam Nabi Yattoo ◽  
Mohammed Sultan Allai ◽  
Bashir Ahmad Khan ◽  
...  

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