serum cytotoxicity
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Author(s):  
A.A. Kotvitska ◽  
R. F. Yeromenko ◽  
V. V. Kozar

THE INFLUENCE OF IMMUNE ACTIVITY COMPOUNDS TO THE BLOOD SERUM CYTOTOXICITY AND THE LEPTIN LEVEL IN THE CONDITIONS OF HYPOESTROGENIA



2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Jean-Baptiste Chanson ◽  
Melissa Alame ◽  
Nicolas Collongues ◽  
Frédéric Blanc ◽  
Marie Fleury ◽  
...  

Neuromyelitis optica (NMO) is an autoimmune disease in which a specific biomarker named NMO-IgG and directed against aquaporin-4 (AQP4) has been found. A correlation between disease activity and anti-AQP4 antibody (Ab) serum concentration or complement-mediated cytotoxicity has been reported, but the usefulness of longitudinal evaluation of these parameters remains to be evaluated in actual clinical practice. Thirty serum samples from 10 NMO patients positive for NMO-IgG were collected from 2006 to 2011. Anti-AQP4 Ab serum concentration and complement-mediated cytotoxicity were measured by flow cytometry using two quantitative cell-based assays (CBA) and compared with clinical parameters. We found a strong correlation between serum anti-AQP4 Ab concentration and complement-mediated cytotoxicity (P<0.0001). Nevertheless, neither relapse nor worsening of impairment level was closely associated with a significant increase in serum Ab concentration or cytotoxicity. These results suggest that complement-mediated serum cytotoxicity assessment does not provide extra insight compared to anti-AQP4 Ab serum concentration. Furthermore, none of these parameters appears closely related to disease activity and/or severity. Therefore, in clinical practice, serum anti-AQP4 reactivity seems not helpful as a predictive biomarker in the followup of NMO patients as a means of predicting the onset of a relapse and adapting the treatment accordingly.



2006 ◽  
Vol 81 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Yukio Yoshida ◽  
Takashi Kishimoto ◽  
Hiroshi Ishiguro ◽  
Yuichiro Nagai ◽  
Keiji Koda ◽  
...  


Vaccine ◽  
2004 ◽  
Vol 22 (29-30) ◽  
pp. 4117-4123 ◽  
Author(s):  
J NEWTON ◽  
R GERAGHTY ◽  
J CASTILLOOLIVARES ◽  
J CARDWELL ◽  
J MUMFORD




2000 ◽  
Vol 32 (5) ◽  
pp. 1102 ◽  
Author(s):  
L Bühler ◽  
S Treter ◽  
I McMorrow ◽  
F.A Neethling ◽  
I Alwayn ◽  
...  


1999 ◽  
Vol 67 (5) ◽  
pp. 658-665 ◽  
Author(s):  
Francisca A. Neethling ◽  
David K.C. Cooper


1999 ◽  
Vol 222 (1-2) ◽  
pp. 31-44 ◽  
Author(s):  
F.A Neethling ◽  
M Koscec ◽  
R Oriol ◽  
D.K.C Cooper ◽  
E Koren


1998 ◽  
Vol 21 (5) ◽  
pp. 191-197 ◽  
Author(s):  
Tatsuo Yamamoto ◽  
Yumi Geshi ◽  
Souichiro Kuno ◽  
Namiko Kase ◽  
Hiroyuki Mori


1995 ◽  
Vol 14 (1) ◽  
pp. 81-90 ◽  
Author(s):  
James C. Keith ◽  
Robert Pijnenborg ◽  
Bernard Spitz ◽  
Myriam Hanssens ◽  
F. Andre Van Assche


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