Nevus pigmentado de junção

This paper presents besides concept and classification of Pigmented Nevus, a case report of a patient with Junctional Pigmented Nevus, localized in the internal mucous of let upper lip. The patient is a 26 years old black woman.

FNA Cytological Diagnosis of Breast Metastasis From a Plantar Melanoma: Case Report

BackgroundBenign and primary malignant breast tumors are quite common, but metastatic malignancies are rare and the diagnosis is challenging due to its low incidence.Case presentationHere, we report a case of metastatic melanoma which was initially diagnosed in breast by fine needle aspiration(FNA). Although the suggestive diagnosis is based on the strong pigmentation of tumor cells in FNA smears, cell block and immunohistochemical melanocyte markers (HMB45 and MART-1) help to confirm the diagnosis. Later, FNAs from lower limb mass and inguinal mass also revealed the same tumor. In addition, a pigmented nevus with the appearance of malignant melanoma was found on the sole of the patient's right foot.Conclusion Our report illustrates the morphological evaluation on cytology，ancillary testing on cell block and meticulous clinical examination play a pivotal role in establishing the correct diagnosis.

A Large Oral Melanoma: A Case Report of a Rare but Aggressive Malignancy

A variety of black-pigmented lesions of the oral cavity can be found, ranging from harmless benign lesions such as melanotic macule, smoker’s melanosis, amalgam/graphite tattoos, and pigmented nevus to a life-threatening oral malignant melanoma. Oral melanoma is a rare and aggressive malignant tumor that originates from melanocytes’ proliferation and accounts for only 0.5% of all oral malignancies. The etiology is unknown. Most oral melanomas are present at the palate and the upper alveolar ridge, whereas occurrences at the buccal mucosa, the lower alveolar ridge, and the lip are rare, with only a few reports in the literature. The diagnosis is confirmed by a biopsy. The prognosis is poor, with a 5-year survival rate of ~20%. In this report, we present a case of large oral melanoma at the right buccal mucosa involving the right lower alveolar ridge and lip commissure, which are relatively unusual locations for oral melanoma. In addition, immunohistochemical markers used for diagnostic, therapeutic, and prognostic decision-making of oral melanoma are also discussed.

Progress in diagnosis and treatment of basal cell carcinoma

Basal cell carcinoma is a common skin carcinogenesis that occurs in the epidermis and the basal layer of the skin.in general, basal cell carcinoma grows slowly, rarely metastasizes, but is locally invasive and destructive. The diagnosis is based on clinical manifestations, but the clinicopathological manifestations are different, and sometimes it is difficult to differentiate from pigmented nevus, malignant melanoma, etc. Therefore, skin biopsy is essential for the diagnosis and assessment of the risk of recurrence.There are many ways to treat basal cell carcinoma. This article reviews the diagnosis and treatment.