The disc embedding theorem provides a detailed proof of the eponymous theorem in 4-manifold topology. The theorem, due to Michael Freedman, underpins virtually all of our understanding of 4-manifolds in the topological category. Most famously, this includes the 4-dimensional topological Poincaré conjecture. Combined with the concurrent work of Simon Donaldson, the theorem reveals a remarkable disparity between the topological and smooth categories for 4-manifolds. A thorough exposition of Freedman’s proof of the disc embedding theorem is given, with many new details. A self-contained account of decomposition space theory, a beautiful but outmoded branch of topology that produces non-differentiable homeomorphisms between manifolds, is provided. Techniques from decomposition space theory are used to show that an object produced by an infinite, iterative process, which we call a skyscraper, is homeomorphic to a thickened disc, relative to its boundary. A stand-alone interlude explains the disc embedding theorem’s key role in smoothing theory, the existence of exotic smooth structures on Euclidean space, and all known homeomorphism classifications of 4-manifolds via surgery theory and the s-cobordism theorem. The book is written to be accessible to graduate students working on 4-manifolds, as well as researchers in related areas. It contains over a hundred professionally rendered figures.