Patch-based approaches to regenerating damaged myocardium include 3D bioprinting of heart patches for epicardial transplantation. By the time this is ready for widespread clinical use, it will be important that patches can be delivered via minimally invasive and robotic surgical approaches. Here, we aimed to design a minimally invasive patch transplantation surgical device for human operation as well as master-slave and fully automated robotic control. METHOD: Over a 12-month period (2019-20) in our multidisciplinary team we designed a surgical instrument to transplant 3D bioprinted heart patches to the epicardial surface. The device was designed for use via uni-portal or multi-portal Video-Assisted Thorascopic Surgery (VATS). Forpreliminary feasibility and sizing, we used a 3D printer to produce a flexible resin model from a computer-aided design (CAD) software platform in preparation for more robust high-resolution metal manufacturing. RESULTS: The instrument was designed as a sheath containing foldable arms, less than 2 cm in diameter when infolded to fit minimally invasive thoracic ports. The total length was 35 cm. When the arms were projected from the sheath, three moveable mechanical arms at the distal end were designed to hold the 3D bioprinted patch. A rotational head allowing for the arms to be angled in real time, a surface with micro-attachment points for patches and a releasing mechanism to release the patch was included. At the proximal end, right-angled handles corresponding to each distal arm could be used to control the distal arms, either manually, or by robotic hardware attached to the arms. CONCLUSION: This world-first design paves the way for a new approach for epicardial patch transplantation via minimally invasive robotic surgery. Full prototyping, proof-of-concept and efficacy trials will be needed to confirm the utility of this approach for translation from bench to bedside.