Enantioselective synthesis of 3-substituted dihydrobenzofurans through iridium-catalyzed intramolecular hydroarylation

The enantioselective cyclization was efficiently catalyzed by a cationic iridium complex coordinated with a conventional chiral bisphosphine ligand to give benzofurans in high yields with high enantioselectivity.

Iron-catalysed enantioselective Suzuki–Miyaura coupling of racemic alkyl bromides

The first iron-catalyzed enantioselective Suzuki–Miyaura coupling reaction has been established by using electron-deficient P-chiral bisphosphine ligand (R,R)-QuinoxP*.

Direct Catalytic Asymmetric Mannich-Type Reaction of an α-CF3 Amide to Isatin Imines

An α-CF3 amide underwent direct asymmetric Mannich-type reaction to isatin imines in the presence of a chiral catalyst comprising a soft Lewis acid Cu(I), a chiral bisphosphine ligand, and Barton’s base. The Mannich adduct was converted in one step into a unique tricycle bearing a trifluoromethylated chiral center and an α-tertiary amine moiety.

Synthesis and application of a new hexamethyl-1,1′-spirobiindane-based chiral bisphosphine (HMSI-PHOS) ligand in asymmetric allylic alkylation

A new class of hexamethyl-1,1′-spirobiindane-based chiral bisphosphine ligand was synthesized and used in Pd-catalyzed asymmetric allylic alkylation reactions.

A supramolecularly tunable chiral diphosphine ligand: application to Rh and Ir-catalyzed enantioselective hydrogenation

A supramolecularly tunable chiral bisphosphine ligand bearing two pyridyl-containing crown ethers was synthesized and applied in Rh or Ir-catalyzed asymmetric hydrogenations in high yields with excellent ee values (90–99% ee).