melatonin 1a receptor
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PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6877 ◽  
Author(s):  
Yifan He ◽  
Wenguo Fan ◽  
Yue Xu ◽  
Yong liang Liu ◽  
Hongwen He ◽  
...  

Melatonin and nitric oxide (NO) are involved in orofacial signal processing in the trigeminal sensory system. The aim of the present study was to examine the distribution of melatonin 1a-receptor (MT1) and its colocalization with nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) in the spinal trigeminal nucleus (STN), the trigeminal ganglion (TG), and the mesencephalic trigeminal nucleus (MTN) in the rat, using histochemistry and immunohistochemistry. Our results show that MT1-positive neurons are widely distributed in the TG and the subnucleus caudalis of the STN. Furthermore, we found that MT1 colocalizes with NADPH-d throughout the TG and MTN, most extensively in the TG. The distribution pattern of MT1 and its colocalization with NADPH-d indicate that melatonin might play an important role in the trigeminal sensory system, which could be responsible for the regulation of NO levels.



2018 ◽  
Vol 13 (4) ◽  
Author(s):  
Vladimir Baturin ◽  
Jury Bykov ◽  
Galina Mamceva ◽  
Tatyana Uglova ◽  
Rosa Yagudina


2010 ◽  
Vol 133 (5) ◽  
pp. 577-584 ◽  
Author(s):  
Shuku Kumasaka ◽  
Masashi Shimozuma ◽  
Tadafumi Kawamoto ◽  
Kenji Mishima ◽  
Reiko Tokuyama ◽  
...  


2008 ◽  
Vol 56 (3) ◽  
pp. 187-195 ◽  
Author(s):  
Yan Wang ◽  
Ke-Mei Peng ◽  
Jian-Li Li ◽  
Hui Song ◽  
Sheng-He Li ◽  
...  


Spine ◽  
2003 ◽  
Vol 28 (17) ◽  
pp. 2025-2028 ◽  
Author(s):  
Jose A. Morcuende ◽  
Raman Minhas ◽  
Lori Dolan ◽  
Jeff Stevens ◽  
John Beck ◽  
...  


2002 ◽  
Vol 32 (1) ◽  
pp. 59-62 ◽  
Author(s):  
Egemen Savaskan ◽  
Gianfranco Olivieri ◽  
Fides Meier ◽  
Lena Brydon ◽  
Ralf Jockers ◽  
...  


2001 ◽  
Vol 15 (8) ◽  
pp. 1306-1317 ◽  
Author(s):  
Cole S. Nelson ◽  
Masayuki Ikeda ◽  
Heinrich S. Gompf ◽  
Mindi L. Robinson ◽  
Nadine K. Fuchs ◽  
...  

Abstract Melatonin is a pineal hormone that regulates seasonal reproduction and has been used to treat circadian rhythm disorders. The melatonin 1a receptor is a seven- transmembrane domain receptor that signals predominately via pertussis toxin-sensitive G-proteins. Point mutations were created at residue N124 in cytoplasmic domain II of the receptor and the mutant receptors were expressed in a neurohormonal cell line. The acidic N124D- and E-substituted receptors had high-affinity 125I-melatonin binding and a subcellular localization similar to the neutral N124N wild-type receptor. Melatonin efficacy for the inhibition of cAMP by N124D and E mutations was significantly decreased. N124D and E mutations strongly compromised melatonin efficacy and potency for inhibition of K+-induced intracellular Ca++ fluxes and eliminated control of spontaneous calcium fluxes. However, these substitutions did not appear to affect activation of Kir3 potassium channels. The hydrophobic N124L and N124A or basic N124K mutations failed to bind 125I-melatonin and appeared to aggregate or traffic improperly. N124A and N124K receptors were retained in the Golgi. Therefore, mutants at N124 separated into two sets: the first bound 125I-melatonin with high affinity and trafficked normally, but with reduced inhibitory coupling to adenylyl cyclase and Ca++ channels. The second set lacked melatonin binding and exhibited severe trafficking defects. In summary, asparagine-124 controls melatonin receptor function as evidenced by changes in melatonin binding, control of cAMP levels, and regulation of ion channel activity. Asparagine-124 also has a unique structural effect controlling receptor distribution within the cell.



1999 ◽  
Vol 262 (3) ◽  
pp. 832-837 ◽  
Author(s):  
Takashi Ebisawa ◽  
Naofumi Kajimura ◽  
Makoto Uchiyama ◽  
Masaaki Katoh ◽  
Masanori Sekimoto ◽  
...  


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