Performance analysis of texture characterization techniques for lung nodule classification

Lung cancer ranks very high on a global index for cancer-related casualties. With early detection of lung cancer, the rate of survival increases to 80-90%. The standard method for diagnosing lung cancer from Computed Tomography (CT) scans is by manual annotation and detection of the cancerous regions, which is a tedious task for radiologists. This paper proposes a machine learning approach for multi-class classification of the lung nodules into solid, semi-solid, and Ground Glass Object texture classes. We employ feature extraction techniques, such as gray-level co-occurrence matrix, Gabor filters, and local binary pattern, and validate the performance on the LNDb dataset. The best performing classifier displays an accuracy of 94% and an F1-score of 0.92. The proposed approach was compared with related work using the same dataset. The results are promising, and the proposed method can be used to diagnose lung cancer accurately.

Improving robustness of a deep learning-based lung-nodule classification model of CT images with respect to image noise

Objective: Robustness is an important aspect to consider, when developing methods for medical image analysis. This study investigated robustness properties of deep neural networks (DNNs) for a lung nodule classification problem based on CT images and proposed a solution to improve robustness. Approach: We firstly constructed a class of four DNNs with different widths, each predicting an output label (benign or malignant) for an input CT image cube containing a lung nodule. These networks were trained to achieve Area Under the Curve of 0.891-0.914 on a testing dataset. We then added to the input CT image cubes noise signals generated randomly using a realistic CT image noise model based on a noise power spectrum at 100 mAs, and monitored the DNN’s output change. We defined $SAR_{5} (\%)$ to quantify the robustness of the trained DNN model, indicating that for $5\%$ of CT image cubes, the noise can change the prediction results with a chance of at least $SAR_{5} (\%)$. To understand robustness, we viewed the information processing pipeline by the DNN as a two-step process, with the first step using all but the last layers to extract representations of the input CT image cubes in a latent space, and the second step employing the last fully-connected layer as a linear classifier to determine the position of the sample representations relative to a decision plane. To improve robustness, we proposed to retrain the last layer of the DNN with a Supporting Vector Machine (SVM) hinge loss function to enforce the desired position of the decision plane. Main results: $SAR_{5}$ ranged in $47.0\sim 62.0\%$ in different DNNs. The unrobustness behavior may be ascribed to the unfavorable placement of the decision plane in the latent representation space, which made some samples be perturbed to across the decision plane and hence susceptible to noise. The DNN-SVM model improved robustness over the DNN model and reduced $SAR_{5}$ by $8.8\sim 21.0\%$. Significance: This study provided insights about the potential reason for the unrobustness behavior of DNNs and the proposed DNN-SVM model improved model robustness.

Deep Learning Methods for Lung Cancer Nodule Classification: A Survey

Lung cancer is one of the leading causes of cancer related deaths. It is due to the complexity of early detection of nodules. In clinical practice, radiologists find it difficult to determine whether a condition is normal or abnormal by manually analysing CT scan or X-ray images for nodule identification. Currently, various deep learning techniques have been developed to identify lung nodules as benign or malignant, but each technique has its own advantages and drawbacks. This work presents a thorough analysis based on segmentation techniques, Related features-based detection, multi-step detection, automatic detection, and deep convolutional neural network techniques. Performance comparison was conducted on a selected works based on performance measures. A potential research direction for the recognition of lung nodules is given at the end of this study.