glycan sequencing
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scholarly journals Mass spectrometry hybridized with gas-phase InfraRed spectroscopy for glycan sequencing

2020 ◽  
Vol 62 ◽  
pp. 121-131 ◽  
Author(s):  
Christopher John Gray ◽  
Isabelle Compagnon ◽  
Sabine L Flitsch
Keyword(s):  
Mass Spectrometry ◽  
Infrared Spectroscopy ◽  
Gas Phase ◽  
Glycan Sequencing

scholarly journals Ion-Mobility Mass Spectrometry of Glycans and Glycopeptides Using Both Intact and Glycan Sequencing Approaches In Positive Ion Mode Facilitates Glycan Isomer and Glycan Motif Identification

2020 ◽  
Author(s):  
Edward Pallister ◽  
Matthew Choo ◽  
ian walsh ◽  
jien nee tai ◽  
Shi-Jie Tay ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Ion Mobility ◽  
Ion Mobility Mass Spectrometry ◽  
Motif Identification ◽  
Glycan Sequencing ◽  
Ion Mobility Spectroscopy ◽  
Positive Ion ◽  
Established Technique ◽  
Ion Analysis

High resolution glycan analysis has become an important part of biopharmaceutical API production and quality control. Liquid chromatography (LC) is now a well-established technique in this field but the resolution of similar isomeric glycan structures is still a challenge. Here we show that the addition of ion mobility spectroscopy (IMS) in a hyphenated LC-IMS-MS setting allows for the high resolution of N-glycan isomers during positive ion analysis. We have identified unique features in the IM chromatograms to help differentiate a range of isomeric N-glycans for both RFMS labelled glycans and glycopeptides.<br>

scholarly journals Ion-Mobility Mass Spectrometry of Glycans and Glycopeptides Using Both Intact and Glycan Sequencing Approaches In Positive Ion Mode Facilitates Glycan Isomer and Glycan Motif Identification

2020 ◽  
Author(s):  
Edward Pallister ◽  
Matthew Choo ◽  
ian walsh ◽  
jien nee tai ◽  
Shi-Jie Tay ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Ion Mobility ◽  
Ion Mobility Mass Spectrometry ◽  
Motif Identification ◽  
Glycan Sequencing ◽  
Ion Mobility Spectroscopy ◽  
Positive Ion ◽  
Established Technique ◽  
Ion Analysis

High resolution glycan analysis has become an important part of biopharmaceutical API production and quality control. Liquid chromatography (LC) is now a well-established technique in this field but the resolution of similar isomeric glycan structures is still a challenge. Here we show that the addition of ion mobility spectroscopy (IMS) in a hyphenated LC-IMS-MS setting allows for the high resolution of N-glycan isomers during positive ion analysis. We have identified unique features in the IM chromatograms to help differentiate a range of isomeric N-glycans for both RFMS labelled glycans and glycopeptides.<br>

scholarly journals Scope and limitations of carbohydrate hydrolysis for de novo glycan sequencing using a hydrogen peroxide/metallopeptide-based glycosidase mimetic

2018 ◽  
Vol 458-459 ◽  
pp. 85-88
Author(s):  
Tianyuan Peng ◽  
Zachary Wooke ◽  
Nicola L.B. Pohl
Keyword(s):  
Hydrogen Peroxide ◽  
De Novo ◽  
Carbohydrate Hydrolysis ◽  
Glycan Sequencing

scholarly journals De Novo Glycan Sequencing by Electronic Excitation Dissociation and Fixed-Charge Derivatization

2018 ◽  
Vol 90 (6) ◽  
pp. 3793-3801 ◽  
Author(s):  
Yang Tang ◽  
Yi Pu ◽  
Jinshan Gao ◽  
Pengyu Hong ◽  
Catherine E. Costello ◽  
...  
Keyword(s):  
Electronic Excitation ◽  
De Novo ◽  
Fixed Charge ◽  
Glycan Sequencing

scholarly journals Automated Glycan Sequencing from Tandem Mass Spectra of N-Linked Glycopeptides

2016 ◽  
Vol 88 (11) ◽  
pp. 5725-5732 ◽  
Author(s):  
Chuan-Yih Yu ◽  
Anoop Mayampurath ◽  
Rui Zhu ◽  
Lauren Zacharias ◽  
Ehwang Song ◽  
...  
Keyword(s):  
Mass Spectra ◽  
Tandem Mass ◽  
Tandem Mass Spectra ◽  
Glycan Sequencing

scholarly journals Eradicating mass spectrometric glycan rearrangement by utilizing free radicals

2016 ◽  
Vol 7 (8) ◽  
pp. 5390-5397 ◽  
Author(s):  
Nikunj Desai ◽  
Daniel A. Thomas ◽  
Jungeun Lee ◽  
Jinshan Gao ◽  
J. L. Beauchamp
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Mass Spectrometric ◽  
Glycan Sequencing

We designed and synthesized a methylated free radical activated glycan sequencing reagent (Me-FRAGS) for eliminating mass spectrometric glycan rearrangement.

Functionalized HgTe nanoparticles promote laser-induced solid phase ionization/dissociation for comprehensive glycan sequencing

The Analyst ◽  
2016 ◽  
Vol 141 (21) ◽  
pp. 6093-6103 ◽  
Author(s):  
Indah Primadona ◽  
Yin-Hung Lai ◽  
Rey Y. Capangpangan ◽  
Rofeamor P. Obena ◽  
Mei-Chun Tseng ◽  
...  
Keyword(s):  
Solid Phase ◽  
Glycan Sequencing

Unambiguous glycan characterization is facilitated by the use of functionalized HgTe nanoparticles.

scholarly journals A method for glycan sequencing

2014 ◽  
Vol 11 (2) ◽  
pp. 129-129
Keyword(s):  
Glycan Sequencing

ChemInform Abstract: Toward a Platform for Comprehensive Glycan Sequencing

ChemInform ◽  
2014 ◽  
Vol 45 (6) ◽  
pp. no-no
Author(s):  
Vernon Reinhold ◽  
Hailong Zhang ◽  
Andrew Hanneman ◽  
David Ashline
Keyword(s):  
Glycan Sequencing
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