A Domino Approach for the Synthesis of 4-Carboxamide Oxazolines from Azirines

A regio- and the diastereoselective ring-expansion reaction of N-acyl aziridine has been described for the synthesis of 4-carboxamide oxazolines using InCl3. A domino Ugi-Joullié/ring expansion reaction of arylphenylazirines, isocyanides, and carboxylic acids led to the target product through N-acylaziridine intermediate in the presence of indium catalyst. The oxazolines were synthesized in moderate to excellent yields with high atom-economy and high bond-forming efficiency under mild reaction conditions.

Catalyst-free synthesis of oxazol-2(3H)-ones from sulfilimines and diazo compounds through a tandem rearrangement/aziridination/ring-expansion reaction

Oxazol-2(3H)-ones play a significant role in the fields of organic synthesis and drug development.

Palladium-Catalyzed Ring-Expansion Reaction of Cyclobutanols with 2-Haloanilines Leading to Benzazepines and Quinolines

A general synthesis of 2-aryl benzazepines has been developed through palladium-catalyzed ring-expansion reaction of cyclobutanols with 2-haloanilines, the further oxidative rearrangement reaction of benzazepines provided an efficient synthesis of 2-acyl...

The Fe(iii)-catalyzed decarboxylative cycloaddition of β-ketoacids and 2H-azirines for the synthesis of pyrrole derivatives

An Fe(iii)-catalyzed Mannich/decarboxylative ring expansion reaction to generate pyrrole derivatives has been achieved using Fe(OTf)3 as the catalyst. A series of pyrrole derivatives was obtained in moderate to excellent yields.