Thermal Properties of Nanotubes and Nanowires With Acoustically Stiffened Surfaces

A core-shell elasticity model is employed to investigate the effect of a nanowire and nanotube’s increased surface moduli on specific heat, ballistic thermal conductance, and thermal conductivity as a function of temperature. Phonon confinement is analyzed using approximated phonon dispersion relations that result from solutions to the frequency equation of a vibrating rod and tube. The results indicate a maximum 10% decrease in lattice thermal conductivity and ballistic thermal conductance near 160 K for a 10 nm outer diameter nanotube with an inner diameter of 5 nm when the average Young’s Modulus of both the inner and outer free surfaces is increased by a factor of 1.53. In the presence of the acoustically stiffened surfaces, the specific heat of the nanotube is found to decrease by up to 20% at 160 K. Near room temperature, changes in thermal properties are less severe. In contrast, a 10 nm outer diameter nanowire composed of similar material exhibits up to a 12% maximum increase in thermal conductivity at 600 K, a 25% increase in ballistic thermal conductance at 400 K, and a 48% increase in specific heat at 470 K when its outer free surface is acoustically stiffened to the same degree. Our simplified model may be extended to investigate the acoustic tuning of nanowires and nanotubes by inducing surface stiffening or softening via appropriate surface chemical functionalization and coatings.

Inferior Colliculus Responses to Multichannel Microstimulation of the Ventral Cochlear Nucleus: Implications for Auditory Brain Stem Implants

Multichannel techniques were used to assess the frequency specificity of activation in the central nucleus of the inferior colliculus (CIC) produced by electrical stimulation of localized regions within the ventral cochlear nucleus (VCN). Data were recorded in response to pure tones from 141 and 193 multiunit clusters in the rat VCN and the CIC, respectively. Of 141 VCN sites, 126 were individually stimulated while recording responses in the CIC. A variety of CIC response types were seen with an increase in both electrical and acoustic stimulation levels. The majority of sites exhibited monotonic rate-level types acoustically, whereas spike rate saturation was achieved predominantly with electrical stimulation. In 20.6% of the 364 characteristic frequency aligned VCN–CIC pairs, the CIC sites did not respond to stimulation. In 26% of the 193 CIC sites, a high correlation was observed between acoustic tuning and electrical tuning obtained through VCN stimulation. A high degree of frequency specificity was found in 58% of the 118 lowest threshold VCN–CIC pairs. This was dependent on electrode placement within the VCN because a higher degree of frequency specificity was achieved with stimulation of medial, central, and posterolateral VCN regions than more anterolateral regions. Broadness of acoustic tuning in the CIC played a role in frequency-specific activation. Narrowly tuned CIC sites showed the lowest degree of frequency specificity on stimulation of the anterolateral VCN regions. These data provide significant implications for auditory brain stem implant electrode placement, current localization, power requirements, and facilitation of information transfer to higher brain centers.

Alterations in Average Spectrum of Cochleoneural Activity by Long-Term Salicylate Treatment in the Guinea Pig: A Plausible Index of Tinnitus

Cazals, Y., K. C. Horner, and Z. W. Huang. Alterations in average spectrum of cochleoneural activity by long-term salicylate treatment in the guinea pig: a plausible index of tinnitus. J. Neurophysiol. 80: 2113–2120, 1998. Salicylate, one of the most widely used drugs, produces at repetitive high doses reversible tinnitus and hearing loss. Neural correlates of hearing loss have long been established, whereas they remain elusive for tinnitus. The average spectrum of electrophysiological cochleoneural activity (ASECA), a measure of spontaneous auditory nerve activity, was monitored in guinea pigs over weeks of salicylate administration. Auditory nerve compound action potential (CAP) was also recorded to monitor acoustic sensitivity. In the first days of treatment, ASECA decreased acutely during hours after salicylate administration; after several days this decrease could be reduced. Over weeks of treatment the level of ASECA increased progressively. No change in CAP threshold was observed. The ASECA decrease induced by a contralateral broadband noise remained unchanged. At the end of treatment, acoustic tuning of ASECA showed a partially decreased sensitivity. After cessation of treatment the ASECA level returned progressively to initial values. In control animals delivery of an ipsilateral acoustic noise could reproduce the ASECA increase observed in long-term salicylate-treated animals. This white noise was of moderate sound pressure level and it elevated slightly CAP thresholds at high frequencies. These data provide evidence for salicylate-induced ASECA alterations without changes in CAP thresholds, in accord with clinical reports of tinnitus being the first subjective sign of salicylate ototoxicity. The similarities in occurrence, development, reversibility, frequency content, and acoustic level support the idea that ASECA changes, which indicates alterations of spontaneous eighth nerve activity and reflects the presence of salicylate-induced high-pitch tinnitus.