The open radio access network (O-RAN) concept is changing the landscape of mobile networks (5G deployment and 6G research). O-RAN Alliance’s suggestions that O-RAN can offer openness and intelligence to the traditional RAN vendors will enable the capability for multi-vendors to re-shape the RAN structure and optimize the network. This paper positions the main research challenges of the O-RAN approach in regards= to the implementation of beamforming. We investigate the O-RAN architecture and the configurations of the interfaces between O-RAN units and present the split options between the radio and distributing units in terms of O-RAN specification and 3GPP standards. From this point, we discuss the beamforming methods in O-RAN, addressing challenges and potential solutions, and suggest the introduction of the zero-forcing equalizer as a precoding vector in the channel-information-based beamforming method. This may be one of the solutions for achieving flexibility in a high-traffic communication environment while reducing the radio unit interferences caused by implanting the precoding in the open radio unit.