a 68930
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DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model

2021 ◽  
Author(s):  
Zhao-Yan Cheng ◽  
Yu-Hui Hu ◽  
Qing-Peng Xia ◽  
Chen Wang ◽  
Ling He
Keyword(s):  
Mouse Model ◽  
Mitochondrial Dysfunction ◽  
Cognitive Deficits ◽  
A 68930

Dopamine D1 receptor agonist A-68930 ameliorates Aβ1-42-induced cognitive impairment and neuroinflammation in mice

2020 ◽  
Vol 88 ◽  
pp. 106963
Author(s):  
Zhao-Yan Cheng ◽  
Qing-Peng Xia ◽  
Yu-Hui Hu ◽  
Chen Wang ◽  
Ling He
Keyword(s):  
Cognitive Impairment ◽  
Receptor Agonist ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
A 68930

scholarly journals Dopamine D1 receptor agonist A-68930 inhibits NLRP3 inflammasome activation and protects rats from spinal cord injury-induced acute lung injury

Spinal Cord ◽  
2016 ◽  
Vol 54 (11) ◽  
pp. 951-956 ◽  
Author(s):  
W Jiang ◽  
M Li ◽  
F He ◽  
Z Bian ◽  
J Liu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Receptor Agonist ◽  
D1 Receptor ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation ◽  
Cord Injury ◽  
A 68930

Dopamine D1 Receptor Agonist A-68930 Inhibits NLRP3 Inflammasome Activation, Controls Inflammation, and Alleviates Histopathology in a Rat Model of Spinal Cord Injury

Spine ◽  
2016 ◽  
Vol 41 (6) ◽  
pp. E330-E334 ◽  
Author(s):  
Wu Jiang ◽  
Yan Huang ◽  
Fan He ◽  
Jia Liu ◽  
Maoqiang Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Nlrp3 Inflammasome ◽  
Receptor Agonist ◽  
D1 Receptor ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation ◽  
Cord Injury ◽  
A 68930

scholarly journals The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Yvonne Connolly Martin
Keyword(s):  
Medicinal Chemistry ◽  
Partial Agonist ◽  
Skf 38393 ◽  
The Novel ◽  
Bioactive Conformation ◽  
Dopaminergic Agonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
A 68930

The novel selective D1 dopaminergic full agonists A-68930, A-77636 were discovered by the synthesis of molecules to probe the bioactive conformation of the partial agonist SKF-38393, by the use of this information to add D1 affinity and selectivity to a screening hit, and by traditional medicinal chemistry exploration of structure-activity relationships. The subsequent design of A-86929 and ABT-413 capitalized on these results, recently disclosed agonists, and traditional medicinal chemistry.

Differential response of A 68930 and sulpiride in stress-induced gastric ulcers in rats

2010 ◽  
Vol 643 (1) ◽  
pp. 121-128 ◽  
Author(s):  
Naila Rasheed ◽  
Ausaf Ahmad ◽  
Neetu Singh ◽  
Pratibha Singh ◽  
Vaibhav Mishra ◽  
...  
Keyword(s):  
Differential Response ◽  
Gastric Ulcers ◽  
A 68930

Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors

2005 ◽  
Vol 82 (3) ◽  
pp. 495-505 ◽  
Author(s):  
R. Nergårdh ◽  
S. Oerther ◽  
B.B. Fredholm
Keyword(s):  
Skf 82958 ◽  
A 68930

A 68930 and dihydrexidine inhibit locomotor activity and d-amphetamine-induced hyperactivity in rats: a role of inhibitory dopamine d1/5 receptors in the prefrontal cortex?

Neuroscience ◽  
2004 ◽  
Vol 124 (1) ◽  
pp. 33-42 ◽  
Author(s):  
R Isacson ◽  
B Kull ◽  
C Wahlestedt ◽  
P Salmi
Keyword(s):  
Prefrontal Cortex ◽  
Locomotor Activity ◽  
A 68930

Sedative effects of the dopamine D1 receptor agonist A 68930 on rat open-field behavior

Neuroreport ◽  
2000 ◽  
Vol 11 (6) ◽  
pp. 1269-1272 ◽  
Author(s):  
Peter Salmi ◽  
Sven Ahlenius
Keyword(s):  
Open Field ◽  
Receptor Agonist ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Open Field Behavior ◽  
Field Behavior ◽  
Sedative Effects ◽  
A 68930
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