Synthesis and Characterization of Host Guest Inclusion Complexes of Cyclodextrin Molecules with Theophylline by Diverse Methodologies

Steady host–guest inclusion complexes have been produced with medicinally important guest molecule theophylline within aqueous α-Cyclodextrin and HP-β-Cyclodextrin. α-and HP-β-Cyclodextrins have been established with favorable structural features for inclusion with Theophylline which include diversified applications in modern science such as controlled delivery in the field of pharmaceuticals, food processing, pesticides, foodstuffs etc. Theophylline is one of the most widely accepted drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD) worldwide, even if it has been used clinically for many years. With both α and HP-β-Cyclodextrins it is found that 1:1 hosts-guest inclusion complexes are formed with the guest molecule theophylline. The construction and quality of the inclusion complexes have been characterized by using conductivity measurement, surface tension study, and Job’s method. The inclusion phenomenon has been confirmed by FTIR spectroscopy, proton NMR study. Association constants and thermodynamic parameters have been evaluated for the created inclusion complexes by ultraviolet spectroscopy.

An environmental remediation: study of molecular interactions of the poorly soluble pharmaceutical drug ibuprofen in aqueous media

Medication disposal today is an alarming issue and gaining much more awareness from the consumers as well as healthcare professionals. Various molecular interactions surviving in aqueous drug systems may be considered responsible for these health hazards. This paper reports an experimental study of the various physico-chemical properties of poorly water soluble drug, ibuprofen in aqueous system. Conductance of ibuprofen been measured in aqueous medium at different concentrations and temperatures (from 298.15 K to 313.15 K), and the sound velocity and surface tension study are done only at 298.15 K. The experimental data have been analyzed to interpret different derived parameters as well some thermo-acoustical parameters. The surface tensionvalues have also been determined by means of Stalagmometer and the obtained values are compared with the values computed from sound velocity and density values. Insights obtained from the present study about different molecular interactions of ibuprofen can assist public health and waste management authorities to improve pharmaceutical resource handling and management in rural and urban areas.

Surface tension study of cationic gemini surfactants binding to DNA

Binding of cationic gemini surfactants alkanediyl-a-ω-bis(dimethyldodecylammonium bromides) with variable polymethylene spacer length ranging from 2 to 12 methylene groups to DNA in NaBr solution is investigated utilizing the tensiometry method. A simple method is presented for calculating the number of surfactant molecules bound to DNA. The results are evaluated in terms of the gemini surfactant spacer length, showing that gemini molecules with either short spacers (2 methylene groups) or long spacers are most efficiently adsorbed to DNA. A weak adsorption to DNA was found for gemini molecules with a medium spacer length (6 methylene groups in the spacer). The binding properties of cationic gemini surfactants as a function of spacer length are consistent with the results obtained by other experimental methods (dynamic light scattering measurements, fluorescence spectroscopy), indicating identical adsorption behaviour of gemini molecules as a function of the spacer length.