A highly secure communication method is essential for end users for the exchange of information which is not interpreted by an intruder. Cryptography plays a crucial role in the current and upcoming digital worlds, for secure data transmission in wired and wireless networks. Asymmetric and symmetric cryptographic algorithms encrypt data against vulnerable attacks and transfer to authenticated users. Steganography is a method for providing secure information with the help of a carrier file (text, video, audio, image, etc.). This paper proposes Deoxyribonucleic Acid (DNA)-based asymmetric algorithm which is used to encrypt the patient’s secret information and its performance is compared with ElGamal, RSA and Diffie–Hellman (DH) cryptographic algorithms. The proposed asymmetric algorithm is applied to image steganography which is used for encrypting and concealing the patient’s secret information in a cover image. The proposed method consumes less hardware resources with improved latency. Dynamic Partial Reconfiguration (DPR) allows to transform a selective area rather than complete shutdown of the entire system during bitstream configuration. Cryptosystem with DPR is designed, synthesized in Xilinx Vivado and simulated in Vivado simulator. The design is targeted at Basys3, Nexys4 DDR and Zync-7000 all-programmable SOC (AP SoC) architectures and programmed with secure partial bit files to avoid vulnerable attacks in the channel.