Cahokia’s role in “Mississippianization”—or the rapid advent of monumental architecture; maize-based subsistence practices; a rich iconography; and social, political, and economic complexity—and its spread or adoption throughout the Midwest and Southeast is intriguing. The question of whether what we see in the archaeological record can be described as an “event” or a “process” drives research into examining cultural change and forces us to critically evaluate what exactly is Mississippian. Recent studies are first recognizing that what we call Mississippian culture is incredibly complex, from individual communities to broad regions whose localized development cannot be overshadowed. Second, researchers acknowledge that change is marked by historic figures, events, places, objects, landscapes, memories, traditions, beliefs, and people. The tangled web of change observed in the archaeological record is further obscured by the temporal and spatial scales of the data. However, creative models and collaborative research are elucidating the variability of Mississippianization from inception, spread, and adoption. The Cahokia site, its rise and fall as an early regional influencer of people both locally and abroad, is an important framework within which to study the development of place, memory, events, cultural traditions, and the last millennia of precontact North America.