This chapter provides an overview of the book's main themes. This book asks two key questions about discourses of trans health: (1) How are ‘trans’ possibilities produced, reified and legitimated through health discourses and practices? (2) How are discourses of trans health negotiated within and between trans community groups, trans activists and health professionals? How are they disseminated, and how are they contested? These questions aim to uncover how trans identities and experiences, along with conceptualisations of trans health, are understood in multiple contexts. The purpose is to grasp the social processes at play in encounters where trans patients feel marginalised, misunderstood, and/or discriminated against.