Skin and Nasal Colonization with Methicillin Resistant Staphylococcus Aureus in Children with Atopic Dermatitis

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease with multifactorial etiologies, Staphylococcus aureus (S.aureus) and methicillinresistant S.aureus (MRSA) that naturally colonize skin and nose are prevalent among children with AD. Objectives: was to determine the prevalence of S.aureus and MRSA colonization of skin lesions and nose of AD children. Methodology: 40 children diagnosed as AD from Dermatology Clinic of Najran Armed Forces Hospital, Saudi Arabia, were included in the study; separate swabs from skin lesions & nose of each AD patient were tested for S.aureus and MRSA colonization using the conventional culture based Vitek 2 system and the molecular BD Max MRSA XT assay. Results: Using the conventional Vitek 2 system, the prevalence of skin and nasal colonization with S.aureus in AD patients were 25% and 30% respectively while skin and nasal colonization with MRSA were 7.5% and 7.5% respectively, the BD Max MRSA XT assay identified correctly S.aureus with overall 96 % sensitivity, 100 % specificity and 98 % diagnostic accuracy and identified 100 % of MRSA strains. Conclusion: The increase in prevalence of skin and nasal colonization with S.aureus and MRSA among AD children raises the concern about importance of the accurate and rapid molecular diagnostic techniques for preventing the potential risk of MRSA transmission

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Colonization with Staphylococcus aureus in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization

Contact Dermatitis ◽

10.1111/cod.13679 ◽

2020 ◽

Vol 83 (6) ◽

pp. 442-449

Author(s):

Line B. Nørreslet ◽

Sofie M. Edslev ◽

Paal S. Andersen ◽

Frederik Plum ◽

Jette Holt ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Hand Eczema ◽

Nasal Colonization

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Role of Staphylococcus aureus Nasal Colonization in Atopic Dermatitis in Infants

Archives of Pediatrics and Adolescent Medicine ◽

10.1001/archpediatrics.2009.117 ◽

2009 ◽

Vol 163 (8) ◽

Cited By ~ 36

Author(s):

Ankie Lebon ◽

Joost A. M. Labout ◽

Henri A. Verbrugh ◽

Vincent W. V. Jaddoe ◽

Albert Hofman ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Nasal Colonization

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Incorrect Data in: Role of Staphylococcus aureus Nasal Colonization in Atopic Dermatitis in Infants: The Generation R Study

Archives of Pediatrics and Adolescent Medicine ◽

10.1001/archpediatrics.2010.27 ◽

2010 ◽

Vol 164 (4) ◽

pp. 334 ◽

Cited By ~ 2

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Nasal Colonization ◽

Incorrect Data

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Persistence of Nasal Colonization with Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Pig Farmers after Holidays from Pig Exposure

Applied and Environmental Microbiology ◽

10.1128/aem.00212-12 ◽

2012 ◽

Vol 78 (11) ◽

pp. 4046-4047 ◽

Cited By ~ 42

Author(s):

Robin Köck ◽

Bea Loth ◽

Mahir Köksal ◽

Josef Schulte-Wülwer ◽

Jürgen Harlizius ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Direct Contact ◽

Methicillin Resistant Staphylococcus Aureus ◽

Nasal Colonization ◽

Methicillin Resistant ◽

Content Type ◽

Mrsa Colonization ◽

Colonization Rates

ABSTRACTLivestock-associated methicillin-resistantStaphylococcus aureus(LA-MRSA) is frequently transmitted from pigs to farmers. This study analyzed whether an absence from direct contact with pigs during holidays had an impact on nasal MRSA colonization rates of pig farmers. Overall, 59% of the farmers did not clear MRSA colonization during their leave.

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295 Epidermal growth factor relieves inflammatory signals in Staphylococcus aureus treated human epidermal keratinocytes and atopic dermatitis-like skin lesions in Nc/Nga mice

Journal of Investigative Dermatology ◽

10.1016/j.jid.2017.07.490 ◽

2017 ◽

Vol 137 (10) ◽

pp. S243

Author(s):

Y. Lee ◽

S. Choi ◽

H. Kang ◽

H. Kim ◽

M. Lee ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Skin Lesions ◽

Epidermal Keratinocytes ◽

Human Epidermal Keratinocytes ◽

Inflammatory Signals ◽

Epidermal Growth

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Methicillin-resistant Staphylococcus aureus colonization among healthcare workers in Oman

The Journal of Infection in Developing Countries ◽

10.3855/jidc.14047 ◽

2021 ◽

Vol 15 (10) ◽

pp. 1426-1435

Author(s):

Loay Al Wahaibi ◽

Rajaa Al Sudairi ◽

Abdullah Balkhair ◽

Huda Al-Awaisi ◽

Mohamed Mabruk

Keyword(s):

Risk Factors ◽

Staphylococcus Aureus ◽

Healthcare Workers ◽

Nasal Swab ◽

Methicillin Resistant Staphylococcus Aureus ◽

Aureus Strain ◽

Nasal Colonization ◽

Methicillin Resistant ◽

Associated Risk Factors ◽

Mrsa Colonization

Introduction: Methicillin-Resistant Staphylococcus aureus (MRSA) is a S. aureus strain characterized by resistance to cloxacillin. Healthcare workers (HCWs), are recognized for their heightened risk for MRSA acquisition and possibly for MRSA nosocomial transmission. This cross-sectional study aimed to determine the prevalence and the associated risk factors of MRSA colonization among healthcare workers at Sultan Qaboos University Hospital (SQUH) in Oman. Methodology: A total of 200 nasal swab samples were collected from the healthcare workers at SQUH during the period October 2nd 2018 to January 7th 2019. All nasal swab samples were examined microbiologically for the presence of MRSA using the standard method and the results were confirmed by detection of the mecA product (PBP2a). Data on associated risk factors for MRSA colonization was collected and analyzed. Results: Forty-one of the 200 screened healthcare workers (20.5%) were found to have nasal carriage of Staphylococcus aureus of which 63.4% were Methicillin Sensitive and 36.6% were Methicillin-Resistant (MRSA). Methicillin-Resistant Staphylococcus aureus (MRSA) was isolated from fifteen of the 200 screened healthcare workers giving a prevalence rate of nasal colonization with MRSA of 7.5%. We found no statistical association between healthcare worker MRSA nasal colonization and age, gender, HCWs specialty, hand hygiene practices, skin condition, previous MRSA infection, and previous exposure to antibiotics. Conclusions: Identification of the prevalence and the associated risk factors of MRSA colonization in healthcare workers mandates continuous surveillance and the implementation of all possible preventive measures to reduce re-occurrences.

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Staphylococcus Aureus Colonization In Atopic Dermatitis Patients

Dermatology and Dermatitis ◽

10.31579/2578-8949/059 ◽

2019 ◽

Vol 4 (3) ◽

pp. 01-08

Author(s):

Nora Harfouch ◽

Fouz Hassan

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Skin Diseases ◽

Normal Skin ◽

Skin Barrier ◽

Nasal Colonization ◽

Cutaneous Infections ◽

Barrier Defect ◽

Inflammatory Skin Disorder ◽

Colonization Rates

Background:Atopic dermatitis (AD) is a common chronic inflammatory skin disorder that induces several symptoms including pruritus and dryness, and is often associated with secondary cutaneous infections. AD is considered to be one of the most prevalent and studied skin diseases yet poorly understood, and its pathophysiology remains obscure. Even though other skin diseases (such as psoriasis) share the same pathologic factor -skin barrier defect - with atopic dermatitis, patients diagnosed with those diseases don't suffer infectious exacerbations like atopic patients do. Aim: Although many international researches have already discussed the relationship between staphylococcus aureus and AD, no studies about this subject in the Arabic region was documented. The aim of our study is to compare staphylococcus aureus colonization rates and densities between atopic dermatitis patients and non-atopic subjects, and to relate the colonization to the severity and duration of the disease. Materials and methods: This observational analytic study included 200 participants (99 diagnosed with atopic dermatitis and 101 control subjects without atopic dermatitis); nasal and skin swabs (lesional and non-lesional) were collected from patients, while nasal and only normal skin swabs were collected from controls. Positive swabs were assessed to determine the density of colonization. Results: 57.6% of patients had nasal colonization, 56.6% had lesional colonization and 30.3% had normal skin colonization. Nasal colonization rates and densities were higher in the patients group. We detected a correlation between colonization and severity of eczema, but no correlation between colonization and duration of the disease was detected. Conclusion: The high rates and densities of staphylococcus aureus colonization in lesional skin of atopic dermatitis patients point out the role of these organisms in the pathophysiology of the disease, put antibiotics on the treatment list of atopic dermatitis and explain infectious features in AD exacerbations.

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Staphylococcus Aureus in the Anterior Nares and Subungual Spaces of the Hands in Atopic Dermatitis

Journal of International Medical Research ◽

10.1177/030006059702500305 ◽

1997 ◽

Vol 25 (3) ◽

pp. 155-158 ◽

Cited By ~ 16

Author(s):

S Nishijima ◽

S Namura ◽

T Higashida ◽

S Kawai

Keyword(s):

Staphylococcus Aureus ◽

Atopic Dermatitis ◽

Skin Diseases ◽

Healthy Adult ◽

Phage Type ◽

Skin Lesions

We examined the prevalence of Staphylococcus aureus in the anterior nares and the subungual spaces of the hands of patients with atopic dermatitis to determine whether the presence of S. aureus at these sites may contribute to the aggravation of the dermatitic skin lesions. The prevalence of S. aureus in the anterior nares of patients with atopic dermatitis was over five times higher than that in the anterior nares of patients with other skin diseases or in healthy adult controls, and the prevalence of S. aureus in the subungual spaces was 10 times higher in patients with atopic dermatitis than in those with other skin diseases or in controls. Both the anterior nares and the subungual spaces of the hands are important reservoirs of S. aureus in atopic dermatitis. The phage type of S. aureus strains isolated from the anterior nares is similar to that of the strains isolated from the subungual spaces.

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