Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. Hypertension Detection and Follow-up Program Cooperative Group. 1979

JAMA ◽  
1997 ◽  
Vol 277 (2) ◽  
pp. 157-166 ◽  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Mild Hypertension ◽  
Cooperative Group ◽  
Hypertension Detection

Haemodynamic Changes Associatedc with Obesity and High Blood Pressure in Crats with Ventromedial Hypothalamic Lesions

1980 ◽  
Vol 59 (s6) ◽  
pp. 397s-399s ◽  
Author(s):  
E. Reisin ◽  
D. H. Suarez ◽  
E. D. Frohlich
Keyword(s):  
Blood Pressure ◽  
Cardiac Output ◽  
High Blood Pressure ◽  
Plasma Volume ◽  
Mild Hypertension ◽  
Male Rats ◽  
Volume Changes ◽  
Hypothalamic Lesions ◽  
Haemodynamic Changes ◽  
Mild Obesity

1. The haemodynamic and plasma volume changes associated with obesity and high blood pressure were studied in nine male rats with electrolytic ventromedial hypothalamic lesions and their paired sham-operated controls. Body weight and arterial pressure were greater in the rats with ventromedial hypothalamic lesions (565 ± 16 vs 462 ± 14 g, P<0.001; 128 ± 3 vs 118 ± 3 mmHg, P<0.05, respectively). Cardiac output was slightly elevated, and that portion of cardiac output distributed to the kidneys was reduced (P<0.001). Plasma volume was contracted in the rats with ventromedial hypothalamic lesions (21.0 ± 0.1 vs 2.8 ± 0.1 ml/100 g, P<0.001). 2. The haemodynamic characteristics of rats in which obesity and mild hypertension have been induced by electrolytic ventromedial hypothalamic lesion are similar to mild obesity essential hypertension in men.

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