Nucleic Acid Enzymes (Ribozymes and Deoxyribozymes): In Vitro Selection and Application

2008 ◽  
Author(s):  
Scott K. Silverman
Keyword(s):  
Nucleic Acid ◽  
In Vitro Selection

In vitro selection of high-affinity nucleic acid ligands to parasite target molecules

2003 ◽  
Vol 33 (12) ◽  
pp. 1309-1317 ◽  
Author(s):  
H.Ulrich Göringer ◽  
Matthias Homann ◽  
Mihaela Lorger
Keyword(s):  
Nucleic Acid ◽  
In Vitro Selection ◽  
High Affinity ◽  
Target Molecules ◽  
Selection Of

Aptamer-based modulation of blood coagulation

2011 ◽  
Vol 31 (04) ◽  
pp. 258-263 ◽  
Author(s):  
F. Rohrbach ◽  
B. Pötzsch ◽  
J. Müller ◽  
G. Mayer
Keyword(s):  
Clinical Trials ◽  
Nucleic Acid ◽  
In Vitro Selection ◽  
Three Dimensional ◽  
Selection Procedure ◽  
Anticoagulant Drugs ◽  
Coagulation Proteins ◽  
Recent Developments ◽  
Target Molecules

SummaryNucleic acid based aptamers are singlestranded oligonucleotide ligands isolated from random libraries by an in-vitro selection procedure. Through the formation of unique three-dimensional structures, aptamers are able to selectively interact with a variety of target molecules and are therefore also promising candidates for the development of anticoagulant drugs. While thrombin represents the most prominent enzymatic target in this field, also aptamers directed against other coagulation proteins and proteases have been identified with some currently being tested in clinical trials.In this review, we summarize recent developments in the design and evaluation of aptamers for anticoagulant therapy and research.

Cell-internalizing nucleic acid aptamers: challenges and cellular uptake mechanisms for applications as pharmacological agents

2021 ◽  
Author(s):  
Samira Husen Alamudi ◽  
Michiko Kimoto ◽  
Ichiro Hirao
Keyword(s):  
Nucleic Acid ◽  
Cellular Uptake ◽  
In Vitro Selection ◽  
Pharmacological Agents ◽  
Nucleic Acid Aptamers ◽  
Uptake Mechanisms ◽  
Targeted Therapeutic

Nucleic acid aptamers, also regarded as chemical antibodies, manifest potentials for targeted therapeutic and delivery agents since they possess unique advantages over antibodies. Generated by an iterative in vitro selection...

[20] In vitro selection of nucleic acid aptamers that bind proteins

1996 ◽  
pp. 336-367 ◽  
Author(s):  
Richard C. Conrad ◽  
Lori Giver ◽  
Yu Tian ◽  
Andrew D. Ellington
Keyword(s):  
Nucleic Acid ◽  
In Vitro Selection ◽  
Nucleic Acid Aptamers ◽  
Selection Of
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