scholarly journals Targeting nucleic acid secondary structures by antisense oligonucleotides designed through in vitro selection.

1996 ◽  
Vol 93 (20) ◽  
pp. 10679-10684 ◽  
Author(s):  
R. K. Mishra ◽  
R. Le Tinevez ◽  
J. J. Toulme
Keyword(s):  
Nucleic Acid ◽  
Antisense Oligonucleotides ◽  
In Vitro Selection ◽  
Secondary Structures

In vitro evaluation of hexitol nucleic acid antisense oligonucleotides

1999 ◽  
Author(s):  
Arthur Van Aerschot ◽  
Mark Vandermeeren ◽  
Johan Geysen ◽  
Walter Luyten ◽  
Marc Miller ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Antisense Oligonucleotides ◽  
In Vitro Evaluation

scholarly journals Rational Design of Short Locked Nucleic Acid-Modified 2′- O -Methyl Antisense Oligonucleotides for Efficient Exon-Skipping In Vitro

2017 ◽  
Vol 9 ◽  
pp. 155-161 ◽  
Author(s):  
Bao T. Le ◽  
Abbie M. Adams ◽  
Susan Fletcher ◽  
Stephen D. Wilton ◽  
Rakesh N. Veedu
Keyword(s):  
Nucleic Acid ◽  
Antisense Oligonucleotides ◽  
Rational Design ◽  
Exon Skipping ◽  
Locked Nucleic Acid

In vitro selection of high-affinity nucleic acid ligands to parasite target molecules

2003 ◽  
Vol 33 (12) ◽  
pp. 1309-1317 ◽  
Author(s):  
H.Ulrich Göringer ◽  
Matthias Homann ◽  
Mihaela Lorger
Keyword(s):  
Nucleic Acid ◽  
In Vitro Selection ◽  
High Affinity ◽  
Target Molecules ◽  
Selection Of

Investigation of twisted intercalating nucleic acid (TINA)-modified antisense oligonucleotides for splice modulation by induced exon-skipping in vitro

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 95169-95172 ◽  
Author(s):  
Bao T. Le ◽  
Vyacheslav V. Filichev ◽  
Rakesh N. Veedu
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Antisense Oligonucleotides ◽  
Exon Skipping

We have investigated the applicability of twisted intercalating nucleic acids (TINA)-modified antisense oligonucleotides (AOs) in exon skipping. We found that TINA-modified AOs induced exon skipping.

Aptamer-based modulation of blood coagulation

2011 ◽  
Vol 31 (04) ◽  
pp. 258-263 ◽  
Author(s):  
F. Rohrbach ◽  
B. Pötzsch ◽  
J. Müller ◽  
G. Mayer
Keyword(s):  
Clinical Trials ◽  
Nucleic Acid ◽  
In Vitro Selection ◽  
Three Dimensional ◽  
Selection Procedure ◽  
Anticoagulant Drugs ◽  
Coagulation Proteins ◽  
Recent Developments ◽  
Target Molecules

SummaryNucleic acid based aptamers are singlestranded oligonucleotide ligands isolated from random libraries by an in-vitro selection procedure. Through the formation of unique three-dimensional structures, aptamers are able to selectively interact with a variety of target molecules and are therefore also promising candidates for the development of anticoagulant drugs. While thrombin represents the most prominent enzymatic target in this field, also aptamers directed against other coagulation proteins and proteases have been identified with some currently being tested in clinical trials.In this review, we summarize recent developments in the design and evaluation of aptamers for anticoagulant therapy and research.

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