Focused Library Design Based on Hit and Target Structures: Method and Application in Drug Discovery

2007 ◽  
pp. 108-124
Author(s):  
Weiliang Zhu ◽  
Jian Li ◽  
Zhen Gong ◽  
Hong Liu ◽  
Hualiang Jiang
Keyword(s):  
Drug Discovery ◽  
Library Design

The maturation of DNA encoded libraries: opportunities for new users

2020 ◽  
Author(s):  
Daniel Conole ◽  
James H Hunter ◽  
Michael J Waring
Keyword(s):  
Data Analysis ◽  
Cost Effectiveness ◽  
Drug Discovery ◽  
High Throughput ◽  
High Throughput Screening ◽  
New Technology ◽  
Combinatorial Libraries ◽  
Library Design ◽  
First Time ◽  
Screening Technology

DNA-encoded combinatorial libraries (DECLs) represent an exciting new technology for high-throughput screening, significantly increasing its capacity and cost–effectiveness. Historically, DECLs have been the domain of specialized academic groups and industry; however, there has recently been a shift toward more drug discovery academic centers and institutes adopting this technology. Key to this development has been the simplification, characterization and standardization of various DECL subprotocols, such as library design, affinity screening and data analysis of hits. This review examines the feasibility of implementing DECL screening technology as a first-time user, particularly in academia, exploring the some important considerations for this, and outlines some applications of the technology that academia could contribute to the field.

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