Regulation of Glycogenolysis in Muscle: Effect of Glucagon and Anoxia on Glycogenolysis in the Perfused Rat Heart; Effect of Adenine Nucleotides, Glucose 6-Phosphate and Inorganic Phosphate on Muscle Phosphorylase Activity.

2008 ◽  
pp. 254-272 ◽  
Author(s):  
H. E. Morgan ◽  
A. Parmeggiani
Keyword(s):  
Rat Heart ◽  
Inorganic Phosphate ◽  
Adenine Nucleotides ◽  
Phosphorylase Activity ◽  
Perfused Rat Heart ◽  
Muscle Phosphorylase ◽  
Muscle Phosphorylase Activity

scholarly journals Intermittent ischemia produces a cumulative depletion of mitochondrial adenine nucleotides in the isolated perfused rat heart.

1990 ◽  
Vol 66 (2) ◽  
pp. 302-310 ◽  
Author(s):  
G K Asimakis ◽  
G S Sandhu ◽  
V R Conti ◽  
L A Sordahl ◽  
J B Zwischenberger
Keyword(s):  
Rat Heart ◽  
Adenine Nucleotides ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart

Increased Muscle Phosphorylase Activity in the Starved Rat

Nature ◽  
1948 ◽  
Vol 162 (4130) ◽  
pp. 1002-1003 ◽  
Author(s):  
KNUD LUNDBÆK ◽  
EWALD S. GORANSON
Keyword(s):  
Phosphorylase Activity ◽  
Muscle Phosphorylase ◽  
Muscle Phosphorylase Activity

scholarly journals Glycogen storage disease associated with glycogen deposition in skeletal and heart muscle with low muscle phosphorylase activity.

1985 ◽  
Vol 74 (7) ◽  
pp. 945-951
Author(s):  
Tatsumi UCHIDA ◽  
Akio KODAMA ◽  
Masatoshi TAKEZAWA ◽  
Mikihiro KIJIMA ◽  
Yoshihiro MIYAZAKI ◽  
...  
Keyword(s):  
Glycogen Storage Disease ◽  
Heart Muscle ◽  
Storage Disease ◽  
Glycogen Storage ◽  
Phosphorylase Activity ◽  
Muscle Phosphorylase ◽  
Glycogen Deposition ◽  
Muscle Phosphorylase Activity

Phosphorylase and glycogen levels in skeletal muscle and liver of hibernating and nonhibernating bats

1959 ◽  
Vol 197 (5) ◽  
pp. 1059-1062 ◽  
Author(s):  
Samuel L. Leonard ◽  
William A. Wimsatt
Keyword(s):  
Skeletal Muscle ◽  
Muscle Glycogen ◽  
Liver Glycogen ◽  
Myotis Lucifugus ◽  
Phosphorylase Activity ◽  
Activity Ratios ◽  
Muscle Phosphorylase ◽  
Wet Weight ◽  
Muscle Phosphorylase Activity ◽  
Made In

Determinations of skeletal muscle and liver glycogen concentration and active a and total t phosphorylase activities were made in bats ( Myotis lucifugus) hibernating at 3°–5° and 20 hours after arousal at room temperature. After arousal, liver glycogen was decreased by half and muscle glycogen was increased over twofold. Concomitantly, muscle phosphorylase a was increased, phosphorylase t was unchanged and the ratio a/t was increased. In the liver, phosphorylase a, t and the ratios were increased upon arousal (calculated per unit of wet weight and per mg N). Epinephrine treatment was ineffective in the torpid hibernating bats, but in aroused bats, it decreased muscle and liver glycogen but increased muscle phosphorylase activity ratios only slightly. Histamine was ineffective in the aroused bats. Stimulating aroused bats to fly for short periods consistently resulted in lower muscle glycogen levels and in no change in muscle phosphorylase activity ratios. It is concluded that a) at least part of the increased muscle glycogen in the aroused bats comes from the liver, b) the changes in glycogen levels and phosphorylase activity are in some manner related and c) liver phosphorylase changes upon arousal, unlike that in muscle phosphorylase, involves an increase in total enzyme potential.

Distribution of adenine nucleotides in the perfused rat heart

1977 ◽  
Vol 232 (5) ◽  
pp. R158-R163
Author(s):  
M. C. Kohn ◽  
M. J. Achs ◽  
D. Garfinkel
Keyword(s):  
Rat Heart ◽  
Adenine Nucleotides ◽  
Physiological State ◽  
Transient Behavior ◽  
Creatine Phosphate ◽  
Short Term ◽  
Computer Technique ◽  
Perfused Rat Heart ◽  
Separate And Unequal

A computer technique for determination of the distribution of adenine nucleotides among compartmented, protonated, and metal-chelated species has been developed for the perfused rat heart. This procedure requires knowledge of tissue levels of creatine, creatine phosphate, ATP, ADP, and AMP and the glycolytic and respiration rates. The method is applicable to any physiological state of the organ and has been applied to transient behavior in aerobic, anoxic, and ischemic hearts. The results suggest that ADP uptake and ATP export by mitochondria are normally linked and equal in rate during aerobic metabolism or short-term anoxia but become separate and unequal during ischemia, so that mitochondrial adenine nucleotides, primarily AMP, accumulate.

Regulation of muscle phosphorylase activity by carnosine and anserine

1982 ◽  
Vol 109 (3) ◽  
pp. 769-775 ◽  
Author(s):  
Peter Johnson ◽  
Joanne S. Fedyna ◽  
Andrew Schindzielorz ◽  
Cindylu Moritz Smith ◽  
Peter J. Kasvinsky
Keyword(s):  
Phosphorylase Activity ◽  
Muscle Phosphorylase ◽  
Muscle Phosphorylase Activity
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