Reference Values for Lung Function in White Children and Adults

2020 ◽  
pp. 463-498
Author(s):  
J.E. Cotes
Keyword(s):  
Lung Function ◽  
Reference Values ◽  
White Children

scholarly journals Reference values of interrupter respiratory resistance in healthy preschool white children

Thorax ◽  
2001 ◽  
Vol 56 (9) ◽  
pp. 691-695
Author(s):  
E Lombardi ◽  
P D Sly ◽  
G Concutelli ◽  
E Novembre ◽  
G Veneruso ◽  
...  
Keyword(s):  
Preschool Children ◽  
Lung Function ◽  
Reference Values ◽  
Univariate Analysis ◽  
Healthy Children ◽  
Respiratory Resistance ◽  
Short Term ◽  
White Children ◽  
History Of

BACKGROUNDInterrupter respiratory resistance (Rint) is reported to be useful in evaluating lung function in poorly collaborating patients. However, no reference values are available from large samples of preschool children using the standard interrupter method. The aim of this study was to define reference Rint values in a population of healthy preschool children.METHODSRint was assessed without supporting the cheeks in children with no history of wheeze from six kindergartens. To evaluate the effects of upper airway compliance on Rint in healthy children, an additional group of preschool children with either no history of wheeze or no respiratory symptoms at the time of testing underwent Rint measurements in our lung function laboratory with and without supporting the cheeks. Short term (about 1 minute apart) and long term (mean 2.5 months apart) repeatability of Rint measurements (2 SDs of the mean paired difference between measurements) was also assessed in children referred for cough or wheeze.RESULTSA total of 284 healthy white children (age range 3.0–6.4 years) were evaluated. Mean inspiratory and expiratory Rint (Rinti and Rinte) did not differ significantly in boys and girls. Age, height, and weight showed a significant inverse correlation with both Rinti and Rinte in the univariate analysis with linear regression. Multiple regression with age, height, and weight as the independent variables showed that all three variables were significantly and independently correlated with Rinti, whereas only height was significantly and independently correlated with Rinte. Supporting the cheeks had no significant effect on Rinti (n=29, median 0.673 v0.660 kPa/l.s, p=0.098) or Rinte (n=39, median 0.702v 0.713 kPa/l.s, p=0.126). Short term repeatability was 0.202 kPa/l.s for Rinti (n=50) and 0.242 kPa/l.s for Rinte (n=69). Long term repeatability was 0.208 kPa/l.s for Rinte (n=26).CONCLUSIONSWe have reported reference Rint values in preschool white children and have demonstrated the usefulness of this technique in assessing lung function in this age group.

Lung Function Reference Values in Chinese Children and Adolescents in Hong Kong

2000 ◽  
Vol 162 (2) ◽  
pp. 424-429 ◽  
Author(s):  
MARY S. M. IP ◽  
EVA M. KARLBERG ◽  
JOHAN P. E. KARLBERG ◽  
KEITH D. K. LUK ◽  
JOHN C. Y. LEONG
Keyword(s):  
Hong Kong ◽  
Lung Function ◽  
Children And Adolescents ◽  
Reference Values ◽  
Chinese Children ◽  
Chinese Children And Adolescents

scholarly journals Global Lung Function Initiative 2012 reference equations for spirometry in the Norwegian population

2016 ◽  
Vol 48 (6) ◽  
pp. 1602-1611 ◽  
Author(s):  
Arnulf Langhammer ◽  
Ane Johannessen ◽  
Turid L. Holmen ◽  
Hasse Melbye ◽  
Sanja Stanojevic ◽  
...  
Keyword(s):  
Lung Function ◽  
Reference Values ◽  
Vital Capacity ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Female Adolescents ◽  
Norwegian Population ◽  
Reference Equations ◽  
Z Scores ◽  
Lower Limit Of Normal

We studied the fit of the Global Lung Function Initiative (GLI) all-age reference values to Norwegians, compared them with currently used references (European Community for Steel and Coal (ECSC) and Zapletal) and estimated the prevalence of obstructive lung disease.Spirometry data collected in 30 239 subjects (51.7% females) aged 12–90 years in three population-based studies were converted to z-scores.We studied healthy non-smokers comprising 2438 adults (57.4% females) aged 20–90 years and 8725 (47.7% female) adolescents aged 12–19 years. The GLI-2012 prediction equations fitted the Norwegian data satisfactorily. Median±sd z-scores were respectively 0.02±1.03, 0.01±1.04 and −0.04±0.91 for forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC in males, and −0.01±1.02, 0.07±0.97 and −0.21±0.82 in females. The ECSC and Zapletal references significantly underestimated FEV1 and FVC. Stricter criteria of obstruction (FEV1/FVC <GLI-2012 lower limit of normal (LLN)) carried a substantially higher risk of obstructive characteristics than FEV1/FVC <0.7 and >GLI-2012 LLN. Corresponding comparison regarding myocardial infarction showed a four-fold higher risk for women.The GLI-2012 reference values fit the Norwegian data satisfactorily and are recommended for use in Norway. Correspondingly, the FEV1/FVC GLI-2012 LLN identifies higher risk of obstructive characteristics than FEV1/FVC <0.7.

scholarly journals Lung function reference values in different German populations

2011 ◽  
Vol 105 (3) ◽  
pp. 352-362 ◽  
Author(s):  
Beate Koch ◽  
Christoph Schäper ◽  
Ralf Ewert ◽  
Henry Völzke ◽  
Anne Obst ◽  
...  
Keyword(s):  
Lung Function ◽  
Reference Values

Assessment of Global Lung Function Initiative (GLI) reference equations for diffusing capacity in relation to respiratory burden in the Swedish CArdioPulmonary bioImage Study (SCAPIS)

2020 ◽  
Vol 56 (2) ◽  
pp. 1901995 ◽  
Author(s):  
Andrei Malinovschi ◽  
Xingwu Zhou ◽  
Björn Bake ◽  
Göran Bergström ◽  
Anders Blomberg ◽  
...  
Keyword(s):  
Lung Function ◽  
Reference Values ◽  
Airflow Limitation ◽  
Diffusing Capacity ◽  
High Resolution Computed Tomography ◽  
Swedish Population ◽  
Reference Equations ◽  
Lms Method ◽  
Never Smokers ◽  
Lower Limit Of Normal

The Global Lung Function Initiative (GLI) has recently published international reference values for diffusing capacity of the lung for carbon monoxide (DLCO). Lower limit of normal (LLN), i.e. the 5th percentile, usually defines impaired DLCO. We examined if the GLI LLN for DLCO differs from the LLN in a Swedish population of healthy, never-smoking individuals and how any such differences affect identification of subjects with respiratory burden.Spirometry, DLCO, chest high-resolution computed tomography (HRCT) and questionnaires were obtained from the first 15 040 participants, aged 50–64 years, of the Swedish CArdioPulmonary bioImage Study (SCAPIS). Both GLI reference values and the lambda-mu-sigma (LMS) method were used to define the LLN in asymptomatic never-smokers without respiratory disease (n=4903, of which 2329 were women).Both the median and LLN for DLCO from SCAPIS were above the median and LLN from the GLI (p<0.05). The prevalence of DLCO <GLI LLN (and also <SCAPIS LLN) was 3.9%, while the prevalence of DLCO >GLI LLN but <SCAPIS LLN was 5.7%. Subjects with DLCO >GLI LLN but <SCAPIS LLN (n=860) had more emphysema (14.3% versus 4.5%, p<0.001), chronic airflow limitation (8.5% versus 3.9%, p<0.001) and chronic bronchitis (8.3% versus 4.4%, p<0.01) than subjects (n=13 600) with normal DLCO (>GLI LLN and >SCAPIS LLN). No differences were found with regard to physician-diagnosed asthma.The GLI LLN for DLCO is lower than the estimated LLN in healthy, never-smoking, middle-aged Swedish adults. Individuals with DLCO above the GLI LLN but below the SCAPIS LLN had, to a larger extent, an increased respiratory burden. This suggests clinical implications for choosing an adequate LLN for studied populations.

Sign in / Sign up

Export Citation Format

Share Document