Tomato Extract and Human Platelet Functions

SummaryThe influence of derivatives of benzamidine, benzylamine and phenylguanidine on platelet function was investigated in vitro. Among the compounds tested 4-nitro-benzoic acid 4’-amidinoanilide, 4-aminobenzoic acid 4’-amidinoanilide, 4-amidino-benzoic acid anilide and 4-amidinobenzoic acid 3’,4’-dimethoxyanilide were found to be potent inhibitors of platelet aggregation induced by ADP, collagen and thrombin. Other platelet functions, such as the thrombin-induced amine liberation, serotonin and adenosine uptake, retraction and phosphodiesterase activity, were not influenced. The action of the benzamidine derivatives, known to be thrombin inhibitors, is not caused by an inhibition of the clotting enzyme, but it seems to be mainly due to the prevention of the ADP effect on platelets.

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PLATELET MEMBRANE GLYCOPROTEINS ABNORMALITIES IN PATIENTS WITH ACUTE LEUKEMIAS AND MALIGNANT LYMPHOMAS

10.1055/s-0038-1643201 ◽

1987 ◽

Author(s):

J Gorski ◽

L Van Hove ◽

F Vanlangendonck ◽

M A Boogaerts ◽

R L Verwilghen ◽

...

Keyword(s):

Flow Cytometry ◽

Bleeding Time ◽

Human Platelet ◽

Myeloproliferative Disorders ◽

Platelet Membrane ◽

Flow Cytometry Analysis ◽

Membrane Glycoproteins ◽

Malignant Lymphomas ◽

Acute Leukemias ◽

Platelet Functions

Membrane glycoproteins are implicated in platelet functions.In myeloproliferative disorders some of the platelet functions are known to be perturbated and an abnormal glycoproteins pattern was demonstrated ear-lier.In this study flow cytometry analysis of human platelet membrane glycoproteins IIa and IIIa in patients with acute leukemias and malignant lymphomas has been performed using monoclonal antibodies against these glycoproteins.A reduction in number of glycoproteins receptors on platelet membrane was demonstrated in patients with acute leukemias and malignant lymphomas in comparison with platelets of healthy donors.In patients with leukemias the positive correlation of percentage of platelets recovered in various density receptor regions to bleeding time and negative correlation to platelet number for both glycoproteins have been found.The study demonstrated that flow cytometry can be a useful method of analysis of platelet membrane glycoproteins, and that the patients with acute leukemias and malignant lymphomas have the number of glycoproteins reduced.

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Lowering of body temperature affects human platelet functions and norepinephrine release

Pharmacology Biochemistry and Behavior ◽

10.1016/0091-3057(94)00432-i ◽

1995 ◽

Vol 51 (2-3) ◽

pp. 217-221 ◽

Cited By ~ 8

Author(s):

Claus Opper ◽

Jürgen Hennig ◽

Christina Clement ◽

Ulrich Laschefski ◽

Daniela Dey ◽

...

Keyword(s):

Body Temperature ◽

Human Platelet ◽

Norepinephrine Release ◽

Platelet Functions

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The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions

Thrombosis and Haemostasis ◽

10.1160/th08-05-0300 ◽

2009 ◽

Vol 101 (02) ◽

pp. 284-289 ◽

Cited By ~ 13

Author(s):

Gianluca Frega ◽

Isabella Savini ◽

Valeria Catani ◽

Antonello Rossi ◽

Luciana Avigliano ◽

...

Keyword(s):

Plasma Membrane ◽

Redox Reactions ◽

Human Platelet ◽

Redox System ◽

Oxygen Species ◽

Plasma Membrane Redox System ◽

Plasma Membrane Redox ◽

Radical Production ◽

Plasma Membrane Electron Transport ◽

Platelet Functions

SummaryThe plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to this system; thus, platelets are also able to counterbalance radical production and to regulate thrombus growth. Aim of this review is to give an update on the plasma membrane redox system in platelets, as well as on its role in platelet functions and leukocyte-platelet crosstalk.

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