Calcium Metabolism and Diseases of the Parathyroid Glands during Pregnancy

Author(s):  
Martin N. Montoro ◽  
T. Murphy Goodwin
1944 ◽  
Vol 43 (6) ◽  
pp. 402-408 ◽  
Author(s):  
Leo Spira

Dystrophies due to chronic fluorine poisoning in organs regulated by the parathyroid glands, namely the skin and its appendages, the nails, teeth and hair, and also in bones, are here shown to be unusually common in this country. They should be regarded as easily detectable signs of a serious disturbance of the calcium metabolism of the body. Fluorine is a poison of which the action, in many respects, is similar to that of arsenic. It is the task of the authorities responsible for the health of the nation to search for ways and means capable of minimizing its effect.I wish to express my sincere thanks to the Librarian of the Royal Society of Medicine and his staff for their never-failing courtesy and help.


2013 ◽  
Vol 16 (4) ◽  
pp. 33-37 ◽  
Author(s):  
Ekaterina Alexandrovna Khantakova ◽  
Larisa Yur'evna Khamnueva ◽  
Galina Mikhailovna Orlova

Objective. To analyze the calcium-phosphorus metabolism in patients with diabetes mellitus (DM) type 1 depending on the functional state of the kidneys. Materials and Methods. The study involved 235 patients with type 1 diabetic (males). One hundred and thirty-four patients entered the group without diabetic nephropathy (DN) and 101 patients entered the group with DN. To study the phosphorous-calcium metabolism in patients with type 1 diabetes there were studied the following parameters in blood plasma: the level of intact parathyroid hormone (PTH), total calcium (Ca), ionized calcium (Ca2+), serum phosphorus (P), as well as calculated CaxP product. Results.  In patients with type 1 diabetes in the progression of DN the increase of P was observed from stage 4 CKD and reduction of Ca ? from CKD stage 5. The increase of the level of PTH was observed from the stage of CKD 3, although isolated cases of secondary hyperparathyroidism were registered in patients with stage CKD 2. At the same time in a large group of the patients with type 1 diabetes there was observed level of PTH below the target values of the stages CKD 3, 4, 5. The deterioration of glycemic control in patients with type 1 diabetes is associated with decreased level of PTH. In patients with type 1 diabetes without DN and with DN there was observed inverse relationship between the level of glycated hemoglobin (HbA. 1c). Conclusion. In patients with type 1 diabetes the progression of DN leads to various disorders of phosphorus-calcium metabolism: reduction of Ca, higher level of P, alter the function of the parathyroid glands (secondary hyperparathyroidism and reduction of PTH below the target value). Deterioration of glycemic control in patients with type 1 diabetes is associated with a reduction of PTH.


1927 ◽  
Vol 23 (1) ◽  
pp. 147-148

At a meeting of the Endocrinological Society on 22/X1926, Prof. V.A. Oppel made an interesting demonstration of a patient with ankylosing inflammation of the spine. Considering the suffering to be caused by hyperfunction of parathyroid glands, responsible for calcium metabolism in organism, Prof. Oppel removed his parathyroid and a part of thyroid gland. The result of the operation was brilliant.


1977 ◽  
Vol 7 (3) ◽  
pp. 513-548 ◽  
Author(s):  
Charles C. Capen ◽  
Sharron L. Martin

1985 ◽  
Vol 66 (3) ◽  
pp. 207-209
Author(s):  
E. M. Shakirova ◽  
S. V. Maltsev ◽  
N. V. Blazhevich

The wide spread of moderate bone changes in young children, the low dependence of mild forms of rickets on the intensity and regularity of preventive measures [1, 12] require clarification of the role of endogenous factors, in particular the endocrine regulation of phosphorus-calcium metabolism in rickets.


2020 ◽  
Vol 23 (2) ◽  
pp. 115-118
Author(s):  
I. V. Makarov ◽  
N. A. Prokofieva

A method is proposed for the integral biochemical diagnostic of primary hyperparathyroidism to obtain reliable information about the functional state of the parathyroid glands, which allows one to assess changes in phosphorus-calcium metabolism, to predict the presence or absence of primary hyperparathyroidism, and also to control the pathological process and the effectiveness of the treatment. To determine a single integral indicator - the index of primary hyperparathyroidism (IPHPT), the ratio of calcium and phosphorus to parathyroid hormone was determined. Measurements were performed in volunteers who don’t suffer from any endocrine pathology (19 patients) and in the group of patients with primary hyperparathyroidism before and after surgical treatment (19 patients). As a result of the study, it was found that the value of IPHPT ≤ 2.46 reliably indicates the presence of primary hyperparathyroidism, and the value of IHPT > 2.46 is a measure for the absence of the parathyroid glands pathology. Thus, the proposed method for the integral biochemical diagnosis of primary hyperparathyroidism could be a reliable quantification technique of the parathyroid glands function, allowing the assessing changes in phosphorus-calcium metabolism, to predict the presence or absence of primary hyperparathyroidism, and also to be used as an objective measure for the effectiveness of the treatment.


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