scholarly journals Feasibility, Reliability, and Sensitivity to Change of Four Radiographic Scoring Methods in Patients With Psoriatic Arthritis

2014 ◽  
Vol 66 (2) ◽  
pp. 311-317 ◽  
Author(s):  
W. Tillett ◽  
D. Jadon ◽  
G. Shaddick ◽  
G. Robinson ◽  
R. Sengupta ◽  
...  
2014 ◽  
Vol 66 (9) ◽  
pp. 1417-1422 ◽  
Author(s):  
Bradly J. Biagioni ◽  
Dafna D. Gladman ◽  
Richard J. Cook ◽  
Lihi Eder ◽  
Anupam Wakhlu ◽  
...  

2011 ◽  
Vol 70 (8) ◽  
pp. 1465-1467 ◽  
Author(s):  
J. Bijsterbosch ◽  
I. K. Haugen ◽  
C. Malines ◽  
E. Maheu ◽  
F. R. Rosendaal ◽  
...  

2019 ◽  
Vol 124 (11) ◽  
pp. 1071-1086 ◽  
Author(s):  
Fausto Salaffi ◽  
Marina Carotti ◽  
Giacomo Beci ◽  
Marco Di Carlo ◽  
Andrea Giovagnoni

2012 ◽  
Vol 39 (11) ◽  
pp. 2189-2192 ◽  
Author(s):  
OLIVER FITZGERALD ◽  
CHRISTOPHER T. RITCHLIN ◽  
PHILIP J. MEASE

Clinical markers of radiographic progression have been studied in patients with psoriatic arthritis (PsA), and results have clearly confirmed the progression of radiographic damage over a 2-year period. Biomarkers of radiographic progression damage (erosion and new bone formation) have also been identified as a critical research issue in these patients. At the 2011 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members discussed development of a pivotal observational study (PsA Biodam study) to determine the validity of several soluble biomarkers in predicting structural damage in patients with PsA receiving standard therapies. Specific protocol issues discussed were the inclusion criteria, selection of candidate biomarkers, timing of sample collection, the primary radiographic outcome measure, radiographic scoring methods, possible substudies, and funding strategies.


2009 ◽  
Vol 301 (8) ◽  
pp. 573-579 ◽  
Author(s):  
Patrick Lee Dominguez ◽  
M. Elaine Husni ◽  
Elizabeth W. Holt ◽  
Stephanie Tyler ◽  
Abrar A. Qureshi

2011 ◽  
Vol 19 ◽  
pp. S189
Author(s):  
K. Leyland ◽  
N. Bottomley ◽  
A. Judge ◽  
T. Spector ◽  
D. Hart ◽  
...  

2014 ◽  
Vol 41 (10) ◽  
pp. 2008-2017 ◽  
Author(s):  
Juan Carlos Torre-Alonso ◽  
Jordi Gratacós ◽  
José Santos Rey-Rey ◽  
Juan Pablo Valdazo de Diego ◽  
Ana Urriticoechea-Arana ◽  
...  

Objective.To develop/validate an instrument to measure health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA), for use in clinical studies.Methods.An item pool of 35 items was generated following standardized procedures. Item reduction was performed using clinimetric and psychometric approaches after administration to 66 patients with PsA. The resulting instrument, the VITACORA-19, consists of 19 items. Its validity content, internal consistency, test-retest reliability, known groups/convergent validity, and sensitivity to change were tested in a longitudinal and multicenter study conducted in 10 hospitals in Spain, with 323 patients who also completed the EuroQol 5-dimensional questionnaire (EQ-5D) and a health status transition item. There were 3 study groups: group A (n = 209, patients with PsA), group B (n = 71, patients with arthritis without psoriatic aspect, patients with arthrosis, and patients with dermatitis), and group C (n = 43, healthy controls).Results.The questionnaire was considered easy/very easy to answer by 94.7% of the patients with PsA. The factorial analysis clearly identified only 1 factor. Cronbach’s alpha coefficient and interclass correlation coefficients exceeded 0.90. Statistically significant differences (p < 0.001) were observed between groups: subjects from group C had better HRQoL, followed by group B, and finally group A had the worst HRQoL. The VITACORA-19 scores showed significant correlations (p < 0.001) to PsA disease activity, EQ-5D, and perceived health state, scoring the patients with better health state higher. The minimum important difference was established as an 8-point change in the global score.Conclusion.The Spanish-developed VITACORA-19, designed to measure HRQoL in patients with PsA, has good validity, reliability, and sensitivity to change.


2011 ◽  
Vol 38 (9) ◽  
pp. 2034-2038 ◽  
Author(s):  
PERNILLE BØYESEN ◽  
FIONA M. McQUEEN ◽  
FRÉDÉRIQUE GANDJBAKHCH ◽  
SIRI LILLEGRAVEN ◽  
LAURA COATES ◽  
...  

Objective.The aim of this multireader exercise was to assess the reliability and sensitivity to change of the psoriatic arthritis magnetic resonance imaging score (PsAMRIS) in PsA patients followed for 1 year.Methods.MRI was acquired from 12 patients with PsA before initiation of treatment and after 12 months. MR images were scored according to PsAMRIS (for synovitis, tenosynovitis, periarticular inflammation, bone marrow edema, bone erosion, and bone proliferation) under standardized conditions, in unknown chronological order. Intraobserver/interobserver reliability was examined by intraclass correlation coefficients (ICC) and sensitivity to change by standardized response means (SRM).Results.The interobserver reliability of PsAMRIS was high for synovitis, tenosynovitis, periarticular inflammation, and bone edema status and change scores (interobserver ICC 0.87–0.97). The intraobserver reliability was moderate to high (ICC 0.60–0.98) for status and change scores, except for change in periarticular inflammation (ICC 0.33). PsAMRIS sensitivity to change was moderate for synovitis, tenosynovitis, and periarticular inflammation (SRM 0.5–0.8), while poor (SRM 0.1–0.3) for bone marrow edema, erosion, and bone proliferation. Rare occurrence and minimal change contributed to poor SRM and change-score ICC for bone parameters.Conclusion.This multireader exercise, performed under standardized conditions, confirmed PsAMRIS to have high interobserver and intraobserver reliability for hand PsA. Measures of inflammation were sensitive to change, implying that PsAMRIS may be a valuable tool for monitoring change in inflammation during PsA clinical trials.


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