Palladium Hydride Nanopocket Cubes and Their H 2 ‐Therapy Function in Amplifying Inhibition of Foam Cells to Attenuate Atherosclerosis

2021 ◽  
pp. 2104892
Author(s):  
Min Xu ◽  
Yue Zhou ◽  
Chuchu Ren ◽  
Xiaoyang Liang ◽  
Nan Li
Keyword(s):  
Foam Cells ◽  
Palladium Hydride

ULTRASONIC ATTENUATION DUE TO ZENER RELAXATION IN SINGLE-CRYSTAL PALLADIUM HYDRIDE

1983 ◽  
Vol 44 (C9) ◽  
pp. C9-419-C9-424
Author(s):  
R. G. Leisure ◽  
T. Kanashiro ◽  
P. C. Riedi ◽  
D. K. Hsu
Keyword(s):  
Single Crystal ◽  
Ultrasonic Attenuation ◽  
Palladium Hydride

Macrophage foam cells and atherosclerosis

10.2741/kruth ◽  
2001 ◽  
Vol 6 (1) ◽  
pp. d429 ◽  
Author(s):  
Howard, S. Kruth
Keyword(s):  
Foam Cells ◽  
Macrophage Foam Cells

Evaluating the effect of cinnamon and rosuvastatin, on the formation of foam cells in macrophages co-cultured with platelets

2021 ◽  
Author(s):  
Maryam Khiabani Rad ◽  
Nader Vazifeh Shiran ◽  
Mohammad Hossien Mohammadi ◽  
Mohsen Hamidpour
Keyword(s):  
Foam Cells

scholarly journals Cholesterol loading suppresses the atheroinflammatory gene polarization of human macrophages induced by colony stimulating factors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jani Lappalainen ◽  
Nicolas Yeung ◽  
Su D. Nguyen ◽  
Matti Jauhiainen ◽  
Petri T. Kovanen ◽  
...  
Keyword(s):  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Foam Cells ◽  
Colony Stimulating Factor ◽  
Human Macrophages ◽  
Gm Csf ◽  
Macrophage Subpopulations ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

AbstractIn atherosclerotic lesions, blood-derived monocytes differentiate into distinct macrophage subpopulations, and further into cholesterol-filled foam cells under a complex milieu of cytokines, which also contains macrophage-colony stimulating factor (M-CSF) and granulocyte–macrophage-colony stimulating factor (GM-CSF). Here we generated human macrophages in the presence of either M-CSF or GM-CSF to obtain M-MØ and GM-MØ, respectively. The macrophages were converted into cholesterol-loaded foam cells by incubating them with acetyl-LDL, and their atheroinflammatory gene expression profiles were then assessed. Compared with GM-MØ, the M-MØ expressed higher levels of CD36, SRA1, and ACAT1, and also exhibited a greater ability to take up acetyl-LDL, esterify cholesterol, and become converted to foam cells. M-MØ foam cells expressed higher levels of ABCA1 and ABCG1, and, correspondingly, exhibited higher rates of cholesterol efflux to apoA-I and HDL2. Cholesterol loading of M-MØ strongly suppressed the high baseline expression of CCL2, whereas in GM-MØ the low baseline expression CCL2 remained unchanged during cholesterol loading. The expression of TNFA, IL1B, and CXCL8 were reduced in LPS-activated macrophage foam cells of either subtype. In summary, cholesterol loading converged the CSF-dependent expression of key genes related to intracellular cholesterol balance and inflammation. These findings suggest that transformation of CSF-polarized macrophages into foam cells may reduce their atheroinflammatory potential in atherogenesis.

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