Controlled Cell Growth and Cell Migration in Periodic Mesoporous Organosilica/Alginate Nanocomposite Hydrogels

Background: Previous studies reported that N-myc downstream-regulated gene 1 (NDRG1) was upregulated in various cancer tissues and decreased expression of miR-188-3p and miR-133b could suppress cell proliferation, metastasis, and invasion and induce apoptosis of cancer cells. However, the molecular mechanism of NRDG1 involved in hepatocellular carcinoma (HCC) tumorigenesis is still unknown. Methods: The expressions of miR-188-3p, miR-133b, and NRDG1 in HCC tissues and cells were quantified by qRT-PCR and Western blot. MTT assay and transwell invasion assay were performed to evaluate cell growth and cell migration, respectively. Luciferase reporter assay were performed to determine whether miR-188-3p and miR-133b could directly bind to NRDG1 in HCC cells. Results: The results showed that NRDG1 was upregulated and these 2 microRNAs were downregulated in HCC tissues. NRDG1 was negatively correlated with miR-188-3p and miR-133b in HCC tissues. MiR-188-3p and miR-133b were demonstrated to directly bind to 3′UTR of NRDG1 and inhibit its expression. Upregulation of miR-188-3p and miR-133b reduced NRDG1 expression in hepatocellular carcinoma cell lines, which consequently inhibited cell growth and cell migration. Conclusions: Our finding suggested that miR-188-3p and miR-133b exert a suppressive effect on hepatocellular carcinoma proliferation, invasion, and migration through downregulation of NDRG1.

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Periodic mesoporous organosilica-coated magnetite nanoparticles combined with lipiodol for transcatheter arterial chemoembolization to inhibit the progression of liver cancer

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2021.02.022 ◽

2021 ◽

Vol 591 ◽

pp. 211-220

Author(s):

Li Liu ◽

Xiangxian Xu ◽

Xianxian Liang ◽

Xiang Zhang ◽

Jun Wen ◽

...

Keyword(s):

Liver Cancer ◽

Magnetite Nanoparticles ◽

Transcatheter Arterial Chemoembolization ◽

Periodic Mesoporous Organosilica ◽

Mesoporous Organosilica ◽

Arterial Chemoembolization

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Controlled PEGylation of periodic mesoporous organosilica nanospheres for improving their stability in physiological solutions

Chinese Chemical Letters ◽

10.1016/j.cclet.2019.02.014 ◽

2019 ◽

Vol 30 (4) ◽

pp. 929-932 ◽

Cited By ~ 5

Author(s):

Xiaodan Su ◽

Jun Tao ◽

Qing Wang ◽

Peng Xu ◽

Wei Luo ◽

...

Keyword(s):

Periodic Mesoporous Organosilica ◽

Mesoporous Organosilica

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Chemical sensors based on nano-sized lanthanide-grafted periodic mesoporous organosilica hybrid materials

Journal of Materials Chemistry C ◽

10.1039/c9tc01328h ◽

2019 ◽

Vol 7 (26) ◽

pp. 8109-8119 ◽

Cited By ~ 8

Author(s):

Anna M. Kaczmarek ◽

Pascal Van Der Voort

Keyword(s):

Hybrid Materials ◽

Chemical Sensors ◽

Aprotic Solvent ◽

Periodic Mesoporous Organosilica ◽

Ion Sensing ◽

Mesoporous Organosilica

Nano-sized PMOs grafted with lanthanides show selective ion sensing for Pb2+ and Cr3+ and strong solvatochromism allowing their use as protic and aprotic solvent sensors.

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