Periodic mesoporous organosilica-coated magnetite nanoparticles combined with lipiodol for transcatheter arterial chemoembolization to inhibit the progression of liver cancer

Background: Transarterial chemoembolization (TACE) is recommended for patients with hepatocellular carcinoma (HCC) in Barcelona Clinic Liver Cancer (BCLC) stage B. However, because of the heterogeneity of HCC in BCLC stage B; various subclassification systems have been proposed to predict the prognosis of patients. Previously, we proposed the Kinki criteria for precise classification of HCC cases in BCLC stage B. In this study, we compared the time to TACE refractoriness in HCC patients with Kinki criteria substages B1 and B2-HCC. Summary: Between January 2006 and December 2013, 592 HCC patients (substage B1, n = 118; substage B2, n = 170) underwent TACE. Time to progression under TACE treatment was defined as the time to untreatable progression (TTUP). TTUP and changes in liver function were analyzed in patients with substages B1 and B2-HCC. The median TTUP was 25.7 months (95% CI 19.3-37.3) and 16.4 months (95% CI 13.1-20.2) in patients with substage B1-HCC and substage B2-HCC, respectively (p = 0.0050). In patients with substage B2-HCC, median Child-Pugh scores after the first TACE session was significantly different from those after third and fifth TACE sessions (first-third, p = 0.0020; first-fifth, p = 0.0008). Key Message: TACE refractoriness occurred earlier in patients with substage B2-HCC than those with substage B1-HCC; deterioration of liver function with repeated TACE was more obvious in HCC cases with stage-B1 tumor. Shorter TTUP and impaired liver function due to repeated TACE could be responsible for the shorter survival in patients with substage B2-HCC.

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Application of Traditional Chinese Medicine Combined with TACE in Patients with Primary Hepatocellular Carcinoma and Its Effect on Liver Function

Proceedings of Anticancer Research ◽

10.26689/par.v1i2.21 ◽

1970 ◽

Vol 1 (2) ◽

Author(s):

Haibin Ding

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Liver Cancer ◽

Liver Function ◽

Recurrence Rate ◽

Transcatheter Arterial Chemoembolization ◽

Primary Liver Cancer ◽

Control Group ◽

Experimental Group ◽

Arterial Chemoembolization

Objective: To analyze the effects of Chinese herbal medicineÂ combined with transcatheter arterial chemoembolization (TACE)Â on liver function in patients with primary hepatocellularCarcinomaÂ (HCC). Methods:Â 122 patients with primary hepatocellularÂ carcinoma admitted inÂ our hospital from March 2014 to OctoberÂ 2016 were divided into experimental group and control groupÂ according to the digital table. The number of each group was theÂ same. The patients in the control group were treated byÂ transcatheter arterial chemoembolization. The experimental groupÂ was treated with traditional Chinese medicine on the basis of theÂ control group. SPSS20.0 statistical software for statistical analysisÂ of two groups of patients with short-term effect, follow-up of oneÂ year primary liver cancer recurrence rate, before and afterÂ treatment WBC count, liver function (alanine aminotransferase),Â alpha-fetoprotein and Karnofsky index parameters. Results:Â â‘ TheÂ total effective rate of the experimental group was significantly higherÂ than that of the control group (P <0.05); â‘¡The relapse rate of theexperimental group was significantly lower than that of the controlÂ group (P <0.05); â‘¢ Before the treatment, the patients in the twoÂ groups had significantly higher recurrence rate than those in theÂ control group (P <0.05). After treatment, the white blood cellÂ count, liver function and alpha-fetoprotein levels in theÂ experimental group were significantly better than those in thecontrol group (P <0.05),Â but no significantÂ difference was foundÂ between the two groups (P<0.05). â‘£ The Karnofsky score of the experimental group wasÂ significantly higher than that of the control group (P<0.05).Â Conclusion:Â Chinese medicine combined with transcatheterÂ arterial chemoembolization in patients with primary liver cancer inÂ the application value is relatively high.

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Effect of Huaier Granule and Transcatheter Arterial Chemoembolization on the Treatment of Advanced Liver Cancer

Journal of Clinical Medicine Research ◽

10.32629/jcmr.v2i3.458 ◽

2021 ◽

Vol 2 (3) ◽

Author(s):

Zheng Yao

Keyword(s):

Survival Rate ◽

Liver Cancer ◽

Transcatheter Arterial Chemoembolization ◽

Combined Treatment ◽

Controlled Study ◽

Therapeutic Effects ◽

Observation Group ◽

Chemotherapy Group ◽

Tace Group ◽

Arterial Chemoembolization

Objective — To explore the effect of Huaier granule combined with transcatheter arterial chemoembolization (TACE) in the treatment of advanced liver cancer. Methods — From January 2017 to January 2020, 150 patients with advanced liver cancer admitted to our hospital were selected as clinical subjects for a prospective non-randomized controlled study based on different treatment schedules. Among them, 50 patients were distributed to TACE group with TACE treatment alone. Besides, 50 patients were assigned to chemotherapy group and received systemic chemotherapy with Folfox4 regimen alone. Among them, 50 patients were distributed as the observation group. The therapeutic effects of the three groups were compared. Results: The effective rate and disease control rate in observation group were significantly higher than those in TACE group and chemotherapy group (P < 0.05). The rate of adr in observation group and TACE group was significantly lower than that in chemotherapy group (P < 0.05). The survival rate of observation group was significantly higher than that of TACE group and chemotherapy group after 12 months follow-up (P < 0.05). Conclusion — The combined treatment of huaier granule and TACE can improve the therapeutic effect and survival rate of patients with advanced liver cancer.

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