Impact of Iron deficiency anaemia on quality of life in patients with ulcerative colitis

2021 ◽  
Author(s):  
Ajay K Jain ◽  
Sandip Vare ◽  
Shohini Sircar ◽  
Amit D. Joshi ◽  
Deepika Jain
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Deficiency Anaemia

scholarly journals Iron Deficiency Anaemia and Quality of Life in Elderly

2018 ◽  
Vol 14 (2) ◽  
Author(s):  
A. Bamanikar ◽  
L. Chatterjee ◽  
B. Vaishnav ◽  
S. Sharma ◽  
S. Rana
Keyword(s):  
Quality Of Life ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Deficiency Anaemia

scholarly journals P478 Treatment with ferric maltol associated with improvements in quality of life for IBD patients with iron deficiency anaemia

2018 ◽  
Vol 12 (supplement_1) ◽  
pp. S346-S346
Author(s):  
C Schmidt ◽  
D Baumgart ◽  
B Bokemeyer ◽  
C Büning ◽  
S Howaldt ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Deficiency Anaemia

scholarly journals P486 Iron deficiency anaemia in inflammatory bowel disease: Diagnosis, quality of life and iron treatment preferences among European patients

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S474-S474
Author(s):  
D Francis ◽  
O Hudson
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Iron Deficiency Anaemia ◽  
Oral Iron ◽  
Daily Activities ◽  
Deficiency Anaemia ◽  
Home Based ◽  
Iv Iron ◽  
Inflammatory Bowel

Abstract Background Iron-deficiency anaemia (IDA) is a major complication in inflammatory bowel disease (IBD). A European patient survey was conducted to analyse the IDA diagnostic journey and the impact of IDA on patients’ quality of life (QoL). Methods This quantitative survey was conducted in the UK, Spain, Italy and Germany between 28 May and 24 August 2020. The questions had been pre-validated by patients in an initial qualitative research phase. Adult patients with IDA associated with IBD and current or last haemoglobin level(s) greater than 8 g/dl, or IDA perceived to be mild or moderate were included. Patients on ferric maltol were excluded due to focus on traditional iron therapies. Selected Short Form-36 measures were used to assess the QoL. Results are presented as the percentage of respondents. Results A total of 173 patients were included (54% female; 98% aged ≤67 years). For months before their IDA diagnosis, most patients experienced IDA symptoms such as extreme fatigue 57%, weakness 45%, headache/dizziness 38% and sleeping difficulty 36%. IDA was typically diagnosed during either regular IBD check-ups or when the patient asked about their symptoms (37% each). Patients felt limited in carrying out daily activities such as running (77%), climbing stairs (65%), or walking more than a mile (64%). As a result of being fatigued, most patients (58%) also felt limited in their ability to complete work or college/university activities. Initially most patients (66%) received oral iron, and 34% received intravenous iron (IV). At the time of the survey, 71% were receiving oral iron and 28% IV iron. In 27% patients, side-effects with both oral and IV irons were the main challenge with IDA treatment. The three most frequently experienced side-effects were, with oral iron: black faeces 42%, stomach pain 37% or constipation 30%; and with IV iron: diarrhoea 23% or headache 21%. One in two patients had to wait 2 or more weeks to start their IV treatment. Once given, 57% patients had to return at least every 1–2 months for new IV iron injections. The majority patients who experienced both oral and IV therapies preferred oral treatments over IV (59% versus 41%). Home-based administration was the predominant reason (by 50%) for oral treatment preference. Most patients (64%) who preferred IV treatment valued fewer side-effects versus oral iron. Conclusion Patients with IBD and IDA are limited in their daily activities. Enduring IDA symptoms such as extreme fatigue often precede and trigger the IDA diagnosis. While challenges remain with both oral and IV irons, oral iron tablets are preferred due to home-based administration. The ongoing COVID pandemic may thus increase the demand for better oral iron treatments of IDA in patients with IBD.

scholarly journals Psychological distress, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis

2017 ◽  
Vol 6 (1) ◽  
pp. 148-158 ◽  
Author(s):  
Börje Jonefjäll ◽  
Magnus Simrén ◽  
Anders Lasson ◽  
Lena Öhman ◽  
Hans Strid
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Ulcerative Colitis ◽  
Psychological Distress ◽  
Iron Deficiency ◽  
Female Gender ◽  
High Fatigue ◽  
Independent Risk Factors ◽  
Active Disease

Background Patients with ulcerative colitis often report fatigue. Objectives To investigate prevalence of and risk factors for fatigue in patients with ulcerative colitis with active disease and during deep remission. Methods In this cross-sectional study, disease activity was evaluated with endoscopy and calprotectin, and patients were classified as having active disease ( n = 133) or being in deep remission ( n = 155). Blood samples were analysed to assess anaemia, iron deficiency and systemic immune activity. Patients completed questionnaires to assess fatigue, psychological distress, gastrointestinal symptoms and quality of life. Results The prevalence of high fatigue (general fatigue ≥ 13, Multidimensional Fatigue Inventory) was 40% in the full study population. Among patients with high fatigue, female gender and iron deficiency were more prevalent, and these patients had more severe disease activity and reported higher levels of anxiety, depression and decreased quality of life compared with patients with no/mild fatigue. A logistic regression analysis identified probable psychiatric disorder (odds ratio (OR) (confidence interval) 6.1 (3.1–12.2)), iron deficiency (OR 2.5 (1.2–5.1)), active disease (OR 2.2 (1.2–3.9)) and female gender (OR 2.1 (1.1–3.7)) as independent risk factors for high fatigue. Similar results were found concerning psychological distress, gender and quality of life, but immune markers did not differ in patients in deep remission with high vs. no/mild fatigue. Conclusions Probable psychiatric disorder, iron deficiency, active disease and female gender are independent risk factors for high fatigue in patients with ulcerative colitis. Low-grade immune activity does not seem to be the cause of fatigue among patients in deep remission.

scholarly journals Iron deficiency anaemia: pathophysiology, assessment, practical management

2022 ◽  
Vol 9 (1) ◽  
pp. e000759
Author(s):  
Aditi Kumar ◽  
Esha Sharma ◽  
Alexandra Marley ◽  
Mark A Samaan ◽  
Matthew James Brookes
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Intravenous Iron ◽  
Deficiency Anaemia ◽  
Inflammatory Conditions ◽  
Common Causes ◽  
Inflammatory Bowel ◽  
Iron Replacement ◽  
In Pregnancy

The WHO has recognised iron deficiency anaemia (IDA) as the most common nutritional deficiency in the world, with 30% of the population being affected with this condition. Although the most common causes of IDA are gastrointestinal bleeding and menstruation in women, decreased dietary iron and decreased iron absorption are also culpable causes. Patients with IDA should be treated with the aim of replenishing iron stores and returning the haemoglobin to a normal level. This has shown to improve quality of life, morbidity, prognosis in chronic disease and outcomes in pregnancy. Iron deficiency occurs in many chronic inflammatory conditions, including congestive cardiac failure, chronic kidney disease and inflammatory bowel disease. This article will provide an updated overview on diagnosis and management of IDA in patients with chronic conditions, preoperative and in pregnancy. We will discuss the benefits and limitations of oral versus intravenous iron replacement in each cohort, with an overview on cost analysis between the different iron formulations currently on the market.

scholarly journals SEOM clinical guidelines for anaemia treatment in cancer patients (2020)

2021 ◽  
Author(s):  
Y. Escobar Álvarez ◽  
R. de las Peñas Bataller ◽  
J. Perez Altozano ◽  
S. Ros Martínez ◽  
A. Sabino Álvarez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Cancer Patients ◽  
Diagnostic Tests ◽  
Iron Deficiency Anaemia ◽  
Blood Products ◽  
Iron Supplements ◽  
Deficiency Anaemia ◽  
Functional Deterioration

AbstractAnaemia is defined by the presence of haemoglobin (Hb) levels < 13 g/dL in men and 12 g/dL in women. Up to 39% of cancer patients present it at the time of diagnosis and up to 40% have iron deficiency. Anaemia causes fatigue, functional deterioration and a reduction in the quality of life; it has also been associated with a poorer response to anti-tumour treatment and lower survival. Basic diagnostic tests for anaemia are simple and should be a routine part of clinical practice. These guidelines review the available evidence on the use of different therapies for treating anaemia: erythropoiesis-stimulating agents, iron supplements, and transfusion of blood products.

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