Growth hormone secretion and its effect on height in pediatric patients with different genotypes of Prader-Willi syndrome

2012 ◽  
Vol 158A (6) ◽  
pp. 1477-1480 ◽  
Author(s):  
Yuji Oto ◽  
Kazuo Obata ◽  
Keiko Matsubara ◽  
Yuki Kozu ◽  
Takayoshi Tsuchiya ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pediatric Patients ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Prader Willi Syndrome

scholarly journals Growth Hormone Secretion After Conformal Radiation Therapy in Pediatric Patients With Localized Brain Tumors

2011 ◽  
Vol 29 (36) ◽  
pp. 4776-4780 ◽  
Author(s):  
Thomas E. Merchant ◽  
Susan R. Rose ◽  
Christina Bosley ◽  
Shengjie Wu ◽  
Xiaoping Xiong ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Radiation Therapy ◽  
Radiation Dose ◽  
Brain Tumors ◽  
Pediatric Patients ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Low Grade ◽  
Conformal Radiation Therapy ◽  
Gh Secretion

Purpose Growth hormone deficiency (GHD) after radiation therapy negatively affects growth and development and quality of life in children with brain tumors. Patients and Materials Between 1997 and 2008, 192 pediatric patients with localized primary brain tumors (ependymoma, n = 88; low-grade glioma, n = 51; craniopharyngioma, n = 28; high-grade glioma, n = 23; and other tumor types, n = 2) underwent provocative testing of GH secretion by using the secretogogues arginine and l-dopa before and after (6, 12, 36, and 60 months) conformal radiation therapy (CRT). A total of 664 arginine/l-dopa test procedures were performed. Results Baseline testing revealed preirradiation GHD in 22.9% of tested patients. On the basis of data from 118 patients, peak GH was modeled as an exponential function of time after CRT and mean radiation dose to the hypothalamus. The average patient was predicted to develop GHD with the following combinations of the time after CRT and mean dose to the hypothalamus: 12 months and more than 60 Gy; 36 months and 25 to 30 Gy; and 60 months and 15 to 20 Gy. A cumulative dose of 16.1 Gy to the hypothalamus would be considered the mean radiation dose required to achieve a 50% risk of GHD at 5 years (TD50/5). Conclusion GH secretion after CRT can be predicted on the basis of dose and time after irradiation in pediatric patients with localized brain tumors. These findings provide an objective radiation dose constraint for the hypothalamus.

Growth Hormone Secretion in Prader-Willi Syndrome

1990 ◽  
Vol 79 (11) ◽  
pp. 1059-1062 ◽  
Author(s):  
H. COSTEFF ◽  
V. A. HOLM ◽  
R. RUVALCABA ◽  
J. SHAVER
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Prader Willi Syndrome

Growth hormone secretion in Prader-Willi syndrome

1998 ◽  
Vol 21 (7) ◽  
pp. 418-422 ◽  
Author(s):  
S. Grosso ◽  
M. Cioni ◽  
S. Buoni ◽  
L. Peruzzi ◽  
L. Pucci ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Prader Willi Syndrome

Growth hormone secretion decreases with age in paediatric Prader-Willi syndrome

2015 ◽  
Vol 83 (2) ◽  
pp. 212-215 ◽  
Author(s):  
M. Cohen ◽  
J. Harrington ◽  
I. Narang ◽  
J. Hamilton
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Prader Willi Syndrome
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