Semaphorin 3A inhibits allergic inflammation by regulating immune responses in a mouse model of allergic rhinitis

2018 ◽  
Vol 9 (5) ◽  
pp. 528-537 ◽  
Author(s):  
Rong Xiang ◽  
Yu Xu ◽  
Wei Zhang ◽  
Yong‐Gang Kong ◽  
Lu Tan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Immune Responses ◽  
Allergic Inflammation ◽  
Semaphorin 3A

scholarly journals Mechanisms of Allergen Immunotherapy in Allergic Rhinitis

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Gabija Drazdauskaitė ◽  
Janice A. Layhadi ◽  
Mohamed H. Shamji
Keyword(s):  
Allergic Rhinitis ◽  
Immune Responses ◽  
Allergen Immunotherapy ◽  
Therapeutic Option ◽  
Nasal Congestion ◽  
Work Productivity ◽  
Allergic Inflammation ◽  
The United States ◽  
Adaptive Immune Responses ◽  
Adaptive Immune

Abstract Purpose of Review Allergic rhinitis (AR) is a chronic inflammatory immunoglobulin (Ig) E-mediated disease of the nasal mucosa that can be triggered by the inhalation of seasonal or perennial allergens. Typical symptoms include sneezing, rhinorrhea, nasal itching, nasal congestion and symptoms of allergic conjunctivitis. AR affects a quarter of the population in the United States of America and Europe. Recent Findings AR has been shown to reduce work productivity in 36–59% of the patients with 20% reporting deteriorated job attendance. Moreover, 42% of children with AR report reduced at-school productivity and lower grades. Most importantly, AR impacts the patient’s quality of life, due to sleep deprivation. However, a proportion of patients fails to respond to conventional medication and opts for the allergen immunotherapy (AIT), which currently is the only disease-modifying therapeutic option. AIT can be administered by either subcutaneous (SCIT) or sublingual (SLIT) route. Both routes of administration are safe, effective, and can lead to tolerance lasting years after treatment cessation. Both innate and adaptive immune responses that contribute to allergic inflammation are suppressed by AIT. Innate responses are ameliorated by reducing local mast cell, basophil, eosinophil, and circulating group 2 innate lymphoid cell frequencies which is accompanied by decreased basophil sensitivity. Induction of allergen-specific blocking antibodies, immunosuppressive cytokines, and regulatory T and B cell phenotypes are key pro-tolerogenic adaptive immune responses. Conclusion A comprehensive understanding of these mechanisms is necessary for optimal selection of AIT-responsive patients and monitoring treatment efficacy. Moreover, it could inspire novel and more efficient AIT approaches.

scholarly journals Berberine reduce allergic inflammation in a house dust mite allergic rhinitis mouse model

2015 ◽  
Vol 53 (4) ◽  
pp. 353-358 ◽  
Author(s):  
B.Y. KIm ◽  
H.R. Park ◽  
H.G. Jeong ◽  
S.W. Kim
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
House Dust ◽  
House Dust Mite ◽  
Allergic Inflammation ◽  
Dust Mite

scholarly journals Bisphenol A Exacerbates Allergic Inflammation in an Ovalbumin-Induced Mouse Model of Allergic Rhinitis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Yunxiu Wang ◽  
Zhiwei Cao ◽  
He Zhao ◽  
Yaoyao Ren ◽  
Liying Hao ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Bisphenol A ◽  
Mrna Level ◽  
Experimental Studies ◽  
Allergic Inflammation ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Protein Levels ◽  
Nasal Symptoms

Purpose. Bisphenol A (BPA) is found in many plastic products and is thus a common environmental endocrine disruptor. Plastic-related health problems, including allergic diseases, are attracting increasing attention. However, few experimental studies have explored the effect of BPA on allergic rhinitis (AR). We explore whether BPA was directly related to the allergic inflammation induced by ovalbumin (OVA) in AR mice. Methods. We first constructed OVA-induced mouse model, and after BPA administration, we evaluated nasal symptoms and measured the serum OVA-specific IgE levels by ELISA. Th2 and Treg-related cytokines of nasal mucosa were measured by cytometric bead array. Th2 and Treg-specific transcription factor levels were assayed by PCR. The proportions of CD3+CD4+IL-4+Th2 and CD4+Helios+Foxp3+ T cells (Tregs) in spleen tissue were determined by flow cytometry. Results. Compared to OVA-only-induced mice, BPA addition increased nasal symptoms and serum OVA-specific IgE levels. OVA and BPA coexposure significantly increased IL-4 and IL-13 protein levels compared to those after OVA exposure alone. BPA plus OVA tended to decrease the IL-10 protein levels compared to those after OVA alone. Coexposure to OVA and BPA significantly increased the GATA-3-encoding mRNA level, and decreased the levels of mRNAs encoding Foxp3 and Helios, compared to those after OVA exposure alone. BPA increased the Th2 cell proportion, and decreased that of Tregs, compared to the levels with OVA alone. Conclusion. BPA exerted negative effects by exacerbating AR allergic symptoms, increasing serum OVA-specific IgE levels, and compromising Th2 and Treg responses.

Immune responses to different patterns of exposure to ovalbumin in a mouse model of allergic rhinitis

2016 ◽  
Vol 273 (11) ◽  
pp. 3783-3788 ◽  
Author(s):  
Mei-Jun Liang ◽  
Qing-Ling Fu ◽  
Hong-Yan Jiang ◽  
Feng-Hong Chen ◽  
Dong Chen ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Immune Responses
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