scholarly journals Pattern recognition to objectively differentiate the etiology of cognitive decay in longitudinal cognitive data: Analysis of stroke, Alzheimer’s disease, and normal aging

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Sean Clouston ◽  
Lauren Richmond ◽  
Stacey Scott ◽  
Christian Luhmann ◽  
Ginny Natale ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pattern Recognition ◽  
Data Analysis ◽  
Normal Aging ◽  
Cognitive Data

scholarly journals Pattern Recognition to Objectively Differentiate the Etiology of Cognitive Decline: Analysis of the Impact of Stroke and Alzheimer’s Disease

2020 ◽  
Vol 54 (6) ◽  
pp. 446-453
Author(s):  
Sean A.P. Clouston ◽  
Lauren L. Richmond ◽  
Stacey B. Scott ◽  
Christian C. Luhmann ◽  
Ginny Natale ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pattern Recognition ◽  
Episodic Memory ◽  
Cognitive Decline ◽  
Multilevel Models ◽  
Cognitive Change ◽  
Normal Aging ◽  
Age Related ◽  
The Impact

<b><i>Background:</i></b> Undetected Alzheimer’s disease (AD) and stroke neuropathology is believed to account for a large proportion of decline in cognitive performance that is attributed to normal aging. This study examined the amount of variance in age-related cognitive change that is accounted for by AD and stroke using a novel pattern recognition protocol. <b><i>Method:</i></b> Secondary analyses of data collected for the Health and Retirement Study (<i>N</i> = 17,579) were used to objectively characterize patterns of cognitive decline associated with AD and stroke. The rate of decline in episodic memory and orientation was the outcome of interest, while algorithms indicative of AD and stroke pathology were the predictors of interest. <b><i>Results:</i></b> The average age of the sample was 67.54 ± 10.45 years at baseline, and they completed, on average, 14.20 ± 3.56 years of follow-up. After adjusting for demographics, AD and stroke accounted for approximately half of age-associated decline in cognition (51.07–55.6% for orientation and episodic memory, respectively) and explained variance attributed to random slopes in longitudinal multilevel models. <b><i>Discussion:</i></b> The results of this study suggested that approximately half of the cognitive decline usually attributed to normal aging are more characteristic of AD and stroke.

Somatostatin-Positive Neurons in the Different Parts of the Brain in Normal Aging and Alzheimer's Disease

Neurosignals ◽  
1996 ◽  
Vol 5 (6) ◽  
pp. 343-348 ◽  
Author(s):  
Wei Ping Li ◽  
Helen W.L. Lai ◽  
Suet Ying Cheng ◽  
David T. Yew
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Normal Aging ◽  
The Brain ◽  
Different Parts

scholarly journals Worries about memory loss and knowledge on Alzheimer's disease in community-dwelling elderly from Brazil

2011 ◽  
Vol 5 (2) ◽  
pp. 108-113 ◽  
Author(s):  
Maria Niures P.S. Matioli ◽  
Arnaldo Etzel ◽  
João A.G.G. Prats ◽  
Wares F. de O. Medeiros ◽  
Taiguara R. Monteiro ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Survey Design ◽  
Memory Loss ◽  
Female Gender ◽  
The Elderly ◽  
Normal Aging ◽  
Community Dwelling ◽  
Study Results ◽  
Memory Screening

Abstract Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Efforts to determine risk factors for the development of AD are important for risk stratification and early diagnosis. Furthermore, there are no standardized practices for memory screening. Lack of knowledge on AD, perception of memory loss as part of normal aging, and poor socioeconomic conditions may also be implicated in the current situation of dementia. Objective: To evaluate knowledge of AD in a literate population of elders and correlate these findings with sociodemographic characteristics. Methods: A descriptive survey design study enrolled 994 volunteers from September 2007 to May 2008 in the city of Santos, São Paulo, Brazil, to answer a brief questionnaire consisting of 8 simple questions about knowledge of AD and worries about memory loss. Results: Greater knowledge about AD was associated with eight or more years of education, female gender and age between 60 and 70 years. Also, 52.8% of responders (95% CI - 49.5-56.0%) answered that memory loss is part of normal aging and 77.5% (95% CI - 74.7-80.1%) had never sought a doctor to evaluate their memories. Conclusion: Our study results reinforced that the first line of preventing late diagnosis of dementia is to act in health promotion, especially by targeting subjects older than 70 years of male gender and with lower educational level. It also provided evidence that strategies to promote physician initiative in treating memory problems are also paramount.

IC-P-164: OASIS-3: LONGITUDINAL NEUROIMAGING, CLINICAL, AND COGNITIVE DATASET FOR NORMAL AGING AND ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_2) ◽  
pp. P138-P138 ◽  
Author(s):  
Pamela J. LaMontagne ◽  
Sarah Keefe ◽  
Wallace Lauren ◽  
Chengjie Xiong ◽  
Elizabeth A. Grant ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Normal Aging

Claudin expression profile separates Alzheimer's disease cases from normal aging and from vascular dementia cases

2012 ◽  
Vol 322 (1-2) ◽  
pp. 184-186 ◽  
Author(s):  
Stefan Spulber ◽  
Nenad Bogdanovic ◽  
Mihaela Oana Romanitan ◽  
Ovidiu A. Bajenaru ◽  
Bogdan O. Popescu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Expression Profile ◽  
Normal Aging
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