Multiple sclerosis in twins from continental Italy and Sardinia: A nationwide study

The incidence of multiple sclerosis (MS) in nurses during the period 1980-1996 was calculated in a nationwide study. The cohort consisted of 69 428 nurses, 2185 men and 67243 women. Sixty (two men and 58 women) with definite MS were observed, whereas 69.3 were expected. We found no significant difference between the observed and expected number of MS cases (standardized incidence ratio =0.87; 95% confidence interval, 0.66-1.12).

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Pregnancy outcome in women with multiple sclerosis: results from a prospective nationwide study in Finland

Multiple Sclerosis Journal ◽

10.1177/1352458510372629 ◽

2010 ◽

Vol 16 (8) ◽

pp. 950-955 ◽

Cited By ~ 66

Author(s):

A. Jalkanen ◽

A. Alanen ◽

L. Airas ◽

Keyword(s):

Multiple Sclerosis ◽

Early Pregnancy ◽

Artificial Insemination ◽

Pregnancy Complications ◽

Expanded Disability Status Scale ◽

Women Of Childbearing Age ◽

Childbearing Age ◽

Nationwide Study ◽

Medical Birth Register ◽

Disability Status

The majority of individuals obtaining the diagnosis of multiple sclerosis are women of childbearing age. They are naturally concerned as to how multiple sclerosis affects the course of pregnancy and the developing foetus. The objective of this study was to prospectively evaluate the incidence of pregnancy complications and delivery risks, and to follow the natural course of multiple sclerosis during and after pregnancy in a cohort of Finnish patients with multiple sclerosis. Sixty-one patients with multiple sclerosis who became pregnant during the years 2003—2005 were prospectively followed-up from early pregnancy until 6 months postpartum. Multiple sclerosis relapses, Expanded Disability Status Scale rates and obstetric details were recorded. The results were compared with the statistics obtained from Finnish Medical Birth Register from the year 2004. We found that patients with multiple sclerosis were no more likely to experience pregnancy complications than Finnish pregnant women generally, but they had a greater likelihood for a need of artificial insemination (4.9% vs. 0.9%; p = 0.0009). Subjects with multiple sclerosis were more likely to undergo assisted vaginal delivery than the at-large cohort(16.4% vs. 6.5%; p = 0.0017). We conclude that pregnancy does not seem to pose a woman with multiple sclerosis to a greater risk for pregnancy complications when compared with women in general. The potential need for instrumental delivery should, however, be taken into account when planning the delivery of a mother with multiple sclerosis.

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Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study

Journal of Neurology ◽

10.1007/s00415-018-9163-6 ◽

2018 ◽

Vol 266 (2) ◽

pp. 481-486 ◽

Cited By ~ 3

Author(s):

Jie Song ◽

Helga Westerlind ◽

Kyla A. McKay ◽

Catarina Almqvist ◽

Pernilla Stridh ◽

...

Keyword(s):

Multiple Sclerosis ◽

Late Onset ◽

Familial Risk ◽

Nationwide Study

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Efficacy of natalizumab in multiple sclerosis patients with high disease activity: a Danish nationwide study

European Journal of Neurology ◽

10.1111/j.1468-1331.2008.02517.x ◽

2009 ◽

Vol 16 (3) ◽

pp. 420-423 ◽

Cited By ~ 59

Author(s):

A. B. Oturai ◽

N. Koch-Henriksen ◽

T. Petersen ◽

P. E. H. Jensen ◽

F. Sellebjerg ◽

...

Keyword(s):

Multiple Sclerosis ◽

Disease Activity ◽

High Disease Activity ◽

Nationwide Study ◽

Multiple Sclerosis Patients

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Vascular comorbidities in multiple sclerosis: a nationwide study from Denmark

Journal of Neurology ◽

10.1007/s00415-016-8295-9 ◽

2016 ◽

Vol 263 (12) ◽

pp. 2484-2493 ◽

Cited By ~ 23

Author(s):

Anja Thormann ◽

Melinda Magyari ◽

Nils Koch-Henriksen ◽

Bjarne Laursen ◽

Per Soelberg Sørensen

Keyword(s):

Multiple Sclerosis ◽

Nationwide Study

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High risk of cardiovascular diseases after diagnosis of multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458513475833 ◽

2013 ◽

Vol 19 (10) ◽

pp. 1336-1340 ◽

Cited By ~ 61

Author(s):

Elham Jadidi ◽

Mohammad Mohammadi ◽

Tahereh Moradi

Keyword(s):

Multiple Sclerosis ◽

Myocardial Infarction ◽

Cardiovascular Diseases ◽

Poisson Regression ◽

Rate Ratio ◽

Incidence Rate Ratio ◽

Matched Control ◽

Country Of Birth ◽

Nationwide Study

Background: Studies of the risk of cardiovascular diseases (CVDs) in patients with multiple sclerosis (MS) have the potential to improve our understanding of the etiology of and the heterogeneity of prognosis and outcomes. Objectives: To investigate the risk of myocardial infarction (MI), stroke, heart failure (HF), and atrial fibrillation (AF) or Flutter in MS patients with different ethnicity, both female and male. Methods: Using Poisson regression, we performed a nationwide study in Sweden to investigate the association between the diagnosis of MS and the risk of MI, stroke, HF, or AF/Flutter in 8281 patients who were hospitalized due to MS from 1987 through 2009, plus 76,640 matched control individuals. We performed stratified analyses by sex, age at follow-up and country of birth. Results: Among MS patients, the incidence rate ratio for MI was 1.85 (95% confidence interval (CI) 1.59 to 2.15), for stroke was 1.71 (95% CI 1.46 to 2.00), for HF was 1.97 (95% CI 1.52 to 2.56) and for AF/Flutter was 0.63 (95% CI 0.46 to 0.87), as compared with individuals without MS. The increased risks were particularly prominent for women. These associations remained after stratification by sex, age and country of birth. Conclusion: We recommend careful surveillance and preventive CVDs measures among MS patients, particularly among the women.

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