scholarly journals A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles

2016 ◽  
Vol 128 (37) ◽  
pp. 11305-11309 ◽  
Author(s):  
Feilin Nie ◽  
Dominique L. Kunciw ◽  
David Wilcke ◽  
Jamie E. Stokes ◽  
Warren R. J. D. Galloway ◽  
...  
2017 ◽  
Vol 15 (26) ◽  
pp. 5585-5592
Author(s):  
Dominique Brossard ◽  
Pascal Retailleau ◽  
Vincent Dumontet ◽  
Philippe Breton ◽  
Sandy Desrat ◽  
...  

Thermic dimerization of methyl 1,3-cyclohexadiene 2-carboxylate gave original 3D-shape compounds by Diels–Alder cycloaddition and original [6 + 4]-ene reaction.


2020 ◽  
Vol 28 (12) ◽  
pp. 115539 ◽  
Author(s):  
Fernanda I. Saldívar-González ◽  
Elena Lenci ◽  
Lorenzo Calugi ◽  
José L. Medina-Franco ◽  
Andrea Trabocchi

MedChemComm ◽  
2014 ◽  
Vol 5 (10) ◽  
pp. 1496-1499 ◽  
Author(s):  
Rongjun He ◽  
Yunpeng Bai ◽  
Zhi-Hong Yu ◽  
Li Wu ◽  
Andrea Michelle Gunawan ◽  
...  

A diversity-oriented synthesis strategy is developed for the discovery of salicylic acid-based drug-like inhibitors for protein tyrosine phosphatases.


RSC Advances ◽  
2021 ◽  
Vol 11 (25) ◽  
pp. 15380-15386
Author(s):  
Dong Ma ◽  
Yang Yin ◽  
Ying-Lu Chen ◽  
Yi-Tao Yan ◽  
Jun Wu

A diverse library of pyrimidine–N-heterocycle hybrids was developed through a step-economical diversity-oriented synthesis strategy. In vivo biological screening showed some derivatives exhibited significant potential herbicidal activity.


2015 ◽  
Vol 13 (15) ◽  
pp. 4570-4580 ◽  
Author(s):  
Albert Isidro-Llobet ◽  
Kathy Hadje Georgiou ◽  
Warren R. J. D. Galloway ◽  
Elisa Giacomini ◽  
Mette R. Hansen ◽  
...  

Macrocyclic peptidomimetics are associated with a broad range of biological activities.


2016 ◽  
Vol 55 (37) ◽  
pp. 11139-11143 ◽  
Author(s):  
Feilin Nie ◽  
Dominique L. Kunciw ◽  
David Wilcke ◽  
Jamie E. Stokes ◽  
Warren R. J. D. Galloway ◽  
...  

Author(s):  
V. Lyandres

Introduction:Effective synthesis of а mobile communication network includes joint optimisation of two processes: placement of base stations and frequency assignment. In real environments, the well-known cellular concept fails due to some reasons, such as not homogeneous traffic and non-isotropic wave propagation in the service area.Purpose:Looking for the universal method of finding a network structure close to the optimal.Results:The proposed approach is based on the idea of adaptive vector quantization of the network service area. As a result, it is reduced to a 2D discrete map split into zones with approximately equal number of service requests. In each zone, the algorithm finds such coordinates of its base station that provide the shortest average distance to all subscribers. This method takes into account the shortage of the a priory information about the current traffic, ensures maximum coverage of the service area, and what is not less important, significantly simplifies the process of frequency assignment.


Sign in / Sign up

Export Citation Format

Share Document