Repurposing π Electrophilic Cyclization/Dealkylation for Group Transfer

2021 ◽  
Author(s):  
Joseph A. Kaplan ◽  
Adena Issaian ◽  
Martin Stang ◽  
David Gorial ◽  
Suzanne A. Blum
Keyword(s):  
Electrophilic Cyclization ◽  
Group Transfer

Repurposing π Electrophilic Cyclization/Dealkylation for Group Transfer

2021 ◽  
Author(s):  
Joseph A. Kaplan ◽  
Adena Issaian ◽  
Martin Stang ◽  
David Gorial ◽  
Suzanne A. Blum
Keyword(s):  
Electrophilic Cyclization ◽  
Group Transfer

Synthesis of Novel Bis-pyrazoles via Electrophilic Cyclization

2019 ◽  
Vol 16 (6) ◽  
pp. 511-516
Author(s):  
Adnan Cetin
Keyword(s):  
13C Nmr ◽  
Cyclization Reaction ◽  
Electrophilic Cyclization ◽  
Pyrazole Derivatives ◽  
Spectral Analyses ◽  
Mass Spectral ◽  
Palladium Catalyzed ◽  
Ft Ir ◽  
Reaction Compound

Efficient steps towards the synthesis of novel (phenyl)(1'-aryl-1,5,5'-triphenyl[3,3'-bi-1Hpyrazol]- 4-yl)methanones 4a-e were developed. The procedure starts from 1-(4-benzoyl-1,5-diphenyl- 1H-3-pyrazolyl)-3-phenyl-2-propyn-1-one (2) which was synthesized by a palladium catalyzed crosscoupling reaction. Compound 2 reacted with various hydrazines to give (E)-(phenyl)[1,5-diphenyl-3- [3-phenyl-1-(2-arylhydrazono)-2-propyn-1-yl]-1H-4-pyrazolyl]methanones E-3a-e. The bis-pyrazole derivatives 4a-e were synthesized from electrophilic cyclization reaction of α,β-acetylenic hydrazones E-3a-e and copper(I) iodide. All synthesized compounds were characterized by FT-IR, 1H, 13C NMR and Mass spectral analyses.

scholarly journals The stereochemical course of phospho group transfer catalyzed by rat liver 6-phosphofructo-2-kinase.

1988 ◽  
Vol 263 (31) ◽  
pp. 16069-16072
Author(s):  
P D Kountz ◽  
S Freeman ◽  
A G Cook ◽  
M R el-Maghrabi ◽  
J R Knowles ◽  
...  
Keyword(s):  
Rat Liver ◽  
Group Transfer

scholarly journals Novel insights into the m6A-RNA methyltransferase METTL3 in cancer

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Yiqing Cai ◽  
Rui Feng ◽  
Tiange Lu ◽  
Xiaomin Chen ◽  
Xiangxiang Zhou ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Human Cancer ◽  
Rna Modification ◽  
Rapid Progression ◽  
Antitumor Therapy ◽  
Promoting Effect ◽  
Methyl Group ◽  
Group Transfer ◽  
Functional Regulation ◽  
Methyl Group Transfer

AbstractN6-methyladenosine (m6A) is a prevalent internal RNA modification in higher eukaryotic cells. As the pivotal m6A regulator, RNA methyltransferase-like 3 (METTL3) is responsible for methyl group transfer in the progression of m6A modification. This epigenetic regulation contributes to the structure and functional regulation of RNA and further promotes tumorigenesis and tumor progression. Accumulating evidence has illustrated the pivotal roles of METTL3 in a variety of human cancers. Here, we systemically summarize the interaction between METTL3 and RNAs, and illustrate the multiple functions of METTL3 in human cancer. METLL3 is aberrantly expressed in a variety of tumors. Elevation of METTL3 is usually associated with rapid progression and poor prognosis of tumors. On the other hand, METTL3 may also function as a tumor suppressor in several cancers. Based on the tumor-promoting effect of METTL3, the possibility of applying METTL3 inhibitors is further discussed, which is expected to provide novel insights into antitumor therapy.

A versatile iodo(iii)etherification of terminal ethynylsilanes using BF3–OiPr2 and alkyl benzyl ethers

2021 ◽  
Author(s):  
Takuya Matsumoto ◽  
Hiroshi Hagiyama ◽  
Kanetsugu Kuribayashi ◽  
Kazuhito Hioki ◽  
Hikaru Fujita ◽  
...  
Keyword(s):  
Benzyl Ether ◽  
Alkoxyl Group ◽  
Group Transfer ◽  
Benzyl Ethers

BF3–OiPr2 and alkyl benzyl ether combining system enables a chemoselective alkoxyl group transfer in the synthesis of (E)-α-silyl-β-alkoxyvinyl-λ3-iodanes.

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