Synthesis of fused dihydrobenzo [4,5]imidazo[1,2-a]pyrmido[5,4-e]pyrmidin-3(4H)-amine derivatives

Some of fused dihydrobenzo [4,5]imidazo [1,2-a] pyrmido [5,4-e] pyrmidin-3(4H)-amine derivatives were synthesized, theses derivatives derived from 4-amino-2-(4-chloro or bromophenyl) -1,2-dihydropyrimido[1,2-a] benzimidazole-3-carbonitrile (4,5), which prepared by reaction 1H-benzimidazol-2-amine (1) and p-chlorobenzaldehyde or p-bromobenzaldehyde (2) and malononitrile (3). These derivatives prepared by reaction compound (4,5) with with triethylorthoformate in presence acetic anhydride to give the products (6,7), then the products was reacted with aliphatic amines (hydrazine, methyl amine, ethyl amine, propyl amine and isobutyl amine) to give pyrmidin rings (8-17) respectively. All these derivatives characterization by FT-IR , HNMR spectra and physical properties.

Synthesis of Novel Bis-pyrazoles via Electrophilic Cyclization

Efficient steps towards the synthesis of novel (phenyl)(1'-aryl-1,5,5'-triphenyl[3,3'-bi-1Hpyrazol]- 4-yl)methanones 4a-e were developed. The procedure starts from 1-(4-benzoyl-1,5-diphenyl- 1H-3-pyrazolyl)-3-phenyl-2-propyn-1-one (2) which was synthesized by a palladium catalyzed crosscoupling reaction. Compound 2 reacted with various hydrazines to give (E)-(phenyl)[1,5-diphenyl-3- [3-phenyl-1-(2-arylhydrazono)-2-propyn-1-yl]-1H-4-pyrazolyl]methanones E-3a-e. The bis-pyrazole derivatives 4a-e were synthesized from electrophilic cyclization reaction of α,β-acetylenic hydrazones E-3a-e and copper(I) iodide. All synthesized compounds were characterized by FT-IR, 1H, 13C NMR and Mass spectral analyses.

Synthesis, Characterization of Poly Heterocyclic Compounds, and Effect on Cancer Cell (Hep-2) In vitro.

A synthesis series of new heterocyclic derivatives (A2-A7) (pyrrole, pyridazine, oxazine and imidazol) derived from 4-acetyl-2,5-dichloro-1-(3,5-dinitrophenyl)-1H-pyrrole-3-carboxylate(A1) have been synthesised. Synthesis of compound (A2) by the reaction of starting material (A1) with hydroxyl amine hydrochloride in the presence of pyridine. Compound (A2) was reacted with hydrazine hydrate in dry benzene to give (A3) derivative. The compound )A3( deals with sodium nitrite to give diazonium salt, and the reaction diazonium salt with ethyl acetoacetate to produce compound (A4). To a mixture of compound (A4) and hydroxyl amine with sttired to yield (A5).Compound (A6) was prepared by reaction compound (A4) with thiosemicarbazide in presence of drops of acetic acid. Synthesis of 1compound (A7) by reaction compound (A6) with ethyl chloro acetate. The reactions have been monitored by TLC and the synthesized compounds were characterized using spectrophotometric methods FT-IR, 1H NMR.The biological effects of the prepared compounds on the cancer cells were studied in vitro. The results indicated that these Synthesized compounds (A1–A7) inhibited1 the cancer1 cells1 efficiently, the compound (A6) was activity inhibited on the cancer cells.

Synthesis and Characterization of Some New Morpholine Derivatives

In this paper a new series of morpholine derivatives was prepared by reacting the morpholine with ethyl chloro acetate in the presence triethylamine as a catalyst in benzene gave morpholin-N-ethyl acetate(1) which reacted with hydrazine hydrate in ethanol, and gave morpholin-N-ethyl acetohydrazide (2) . Morpholin-N-aceto semithiocarbazide (3) were prepared by reacting compound(2) with ammonium thiocyanate , concentrated hydrochloric acid and ethanol as a solvent .Compound (3) reacted with sodium hydroxide and hydrochloric acid to give 5-(morpholin-N-methylene)-1H-1,2,4-triazole-3-thiol (4) .The new series of 1,2,4-triazol derivatives (5-8) was synthesized by reaction of compound(4) with formaldehyde , DMF as a solvent and different secondary amines. Preparation of new 1,2,4-triazoline derivatives (9) by reaction compound (4) with bromo acetic acid . Reaction of compound (9) with different aromatic aldehyde and dimethyl sulfoxide as a solvent obtained compounds (10-13).

The Nature of Intermetallic Compounds and its Effect on Mechanical Properties of Cu/Al/Cu Clad Metals

The mechanical properties and microstructure of layered Cu/Al/Cu composites was investigated after annealing at various temperatures. The nature of intermetallic compounds in roll-bonded Cu/Al/Cu clad metals after heat treatment was investigated using SEM, XRD and EBSD.in the temperature range 200~500oC. In the roll-bonded 3-ply Cu/Al/Cu clad metal, no visible interfacial reaction compound and defects were observed at the interfaces. The reaction layer was observed grow rapidly at the Cu/Al interface after annealing at and above 400oC, which deteriorated the ductility of clad metals. Intermetallic reaction layers of Cu/Al/Cu clad materials annealed at 500oC for 3, 5, 10hours was found to consist of three layers, CuAl2, CuAl and Cu9Al4. EBSD analyses revealed that intermetallic layers are polycrystalline. The drastic decrease of stress and elongation in Cu/Al/Cu clad composite annealed at 500oC can be linked to the interfacial cracks between Al and Cu layer.

Mechanical Performance and Fracture of 3-Ply Cu/Al/Cu Clad Metals

The mechanical performance and fracture of roll-bonded Cu/Al/Cu clad metal were investigated after heat treatment in the temperature range 200~500OC. In the roll-bonded 3-ply Cu/Al/Cu clad metal, no visible interfacial reaction compound and defects were observed at the interfaces, ensuring the well-bonded Cu/Al interface until the final moment of fracture in tension. The reaction layer was observed at the Cu/Al interface after annealing at and above 400OC, which deteriorated the ductility of clad metals. The thickness of the reaction layer increased with increasing heat treatment temperature. The periodic cracks were formed perpendicular to the tensile direction due to the strain mismatch between metal layers and the reaction compound layer in the clad heat treated at high temperatures at 500oC. The slip localization and delamination induced premature crack formation in Cu and Al layer, resulting in the decreased clad metal fracture strain, especially after heat treating at 500oC.

Beiträge zur Chemie des Phosphors, 234 [1,2] Lithium-tetrahydrogencyclopentaphosphid: Synthese, Struktur und Reaktionen / Contributions to the Chemistry of Phosphorus, 234 [1,2] Lithium Tetrahydrogen Cyclopentaphosphide: Synthesis, Structure and Reactions

Lithium tetrahydrogen cyclopentaphosphide. LiH4P5 (I). has been obtained by metalation of P2H4 at -78 °C with either n-BuLi or LiPH2 in polar solvents. Upon suitable performance of the reaction, compound I can be isolated at low temperature as a lemon-yellow solvent adduct. The structure as the monolithium salt of (PH)5 was confirmed by a complete analysis of the 31P{1H}-NMR spectrum. On warming above -35 °C, disproportionation occurs yield­ing Li2HP7. P2H4. and PH3. The reaction with n-BuLi produces the open-chain phosphides LiH4P3. LiH3P2, and LiPH2. The NMR parameters of LiH3P2 and LiH4P3 are reported. Reac­tion of 1 with P2H4 gives rise to the bicyclic and polycyclic phosphides LiH4P7, LiH5P8 and Li2H2P14, respectively.