Chiral Carbon Dots Mimicking Topoisomerase I To Mediate the Topological Rearrangement of Supercoiled DNA Enantioselectively

2020 ◽  
Vol 59 (27) ◽  
pp. 11087-11092 ◽  
Author(s):  
Feng Li ◽  
Shuai Li ◽  
Xiaocui Guo ◽  
Yuhang Dong ◽  
Chi Yao ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Topoisomerase I ◽  
Supercoiled Dna ◽  
Chiral Carbon

Chiral Carbon Dots Mimicking Topoisomerase I To Mediate the Topological Rearrangement of Supercoiled DNA Enantioselectively

2020 ◽  
Vol 132 (27) ◽  
pp. 11180-11185 ◽  
Author(s):  
Feng Li ◽  
Shuai Li ◽  
Xiaocui Guo ◽  
Yuhang Dong ◽  
Chi Yao ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Topoisomerase I ◽  
Supercoiled Dna ◽  
Chiral Carbon

Formation Mechanism and Chirality Evolution of Chiral Carbon Dots Prepared via Radical Assisted Synthesis at Room Temperature

Nanoscale ◽  
2021 ◽  
Author(s):  
Lorenzo Branzi ◽  
Giacomo Lucchini ◽  
Elti Cattaruzza ◽  
Nicola Pinna ◽  
Alvise Benedetti ◽  
...  
Keyword(s):  
Thermal Treatment ◽  
Formation Mechanism ◽  
Carbon Dots ◽  
Room Temperature ◽  
Chiral Carbon

We report on a Cu(II) catalyzed process for the production of cysteine based chiral carbon dots, the process does not require any thermal treatment and the carbon dots formation is...

scholarly journals Role of a tryptophan anchor in human topoisomerase I structure, function and inhibition

2008 ◽  
Vol 411 (3) ◽  
pp. 523-530 ◽  
Author(s):  
Gary S. Laco ◽  
Yves Pommier
Keyword(s):  
Amino Acids ◽  
Topoisomerase I ◽  
Electrostatic Interactions ◽  
Functional Domain ◽  
Site Mutation ◽  
Supercoiled Dna ◽  
Terminal Domain ◽  
Tryptophan Residues ◽  
N Terminus

Human Top1 (topoisomerase I) relaxes supercoiled DNA during cell division and transcription. Top1 is composed of 765 amino acids and contains an unstructured N-terminal domain of 200 amino acids, and a structured functional domain of 565 amino acids that binds and relaxes supercoiled DNA. In the present study we examined the region spanning the junction of the N-terminal domain and functional domain (junction region). Analysis of several published Top1 structures revealed that three tryptophan residues formed a network of aromatic stacking interactions and electrostatic interactions that anchored the N-terminus of the functional domain to sub-domains containing the nose cone and active site. Mutation of the three tryptophan residues (Trp203/Trp205/Trp206) to an alanine residue, either individually or together, in silico revealed that the individual tryptophan residue's contribution to the tryptophan ‘anchor’ was additive. When the three tryptophan residues were mutated to alanine in vitro, the resulting mutant Top1 differed from wild-type Top1 in that it lacked processivity, exhibited resistance to camptothecin and was inactivated by urea. The results indicated that the tryptophan anchor stabilized the N-terminus of the functional domain and prevented the loss of Top1 structure and function.

Chiral Carbon Dots-Enzyme Nanoreactors with Enhanced Catalytic Activity for Cancer Therapy

2021 ◽  
Author(s):  
Pengli Gao ◽  
Shuang Chen ◽  
Shi Liu ◽  
Hongxin Liu ◽  
Zhigang Xie ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Cancer Therapy ◽  
Carbon Dots ◽  
Chiral Carbon

scholarly journals Tuning residual chirality in carbon dots with anti-microbial properties

RSC Advances ◽  
2020 ◽  
Vol 10 (53) ◽  
pp. 32202-32210
Author(s):  
Florence Victoria ◽  
John Manioudakis ◽  
Liana Zaroubi ◽  
Brandon Findlay ◽  
Rafik Naccache
Keyword(s):  
Escherichia Coli ◽  
Carbon Dots ◽  
Microbial Properties ◽  
Chiral Carbon

Chiral carbon dots, prepared from the unnatural d-enantiomer of cysteine, inhibit the growth of Escherichia coli ATCC 25922 and MG1655 at a lower concentration than l-carbon dots, prepared from the l-enantiomer.

scholarly journals Camptothecin-sensitive Relaxation of Supercoiled DNA by the Topoisomerase I-like Activity Associated with Poly(ADP-ribose) Polymerase-1

2004 ◽  
Vol 279 (12) ◽  
pp. 11992-11999 ◽  
Author(s):  
Tetsu M. C. Yung ◽  
Marianne Parent ◽  
Erick L. Y. Ho ◽  
Masahiko S. Satoh
Keyword(s):  
Topoisomerase I ◽  
Supercoiled Dna

scholarly journals Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA

FEBS Journal ◽  
2009 ◽  
Vol 276 (20) ◽  
pp. 5906-5919 ◽  
Author(s):  
Zheng Yang ◽  
James F. Carey ◽  
James J. Champoux
Keyword(s):  
Topoisomerase I ◽  
Mutational Analysis ◽  
Supercoiled Dna ◽  
Preferential Binding

Aggregation-induced red shift in N,S-doped chiral carbon dot emissions for moisture sensing

2019 ◽  
Vol 43 (33) ◽  
pp. 13240-13248 ◽  
Author(s):  
Farwa Arshad ◽  
Md Palashuddin Sk
Keyword(s):  
Organic Solvents ◽  
Carbon Dots ◽  
Red Shift ◽  
Commercial Products ◽  
Carbon Dot ◽  
Chiral Carbon ◽  
Moisture Sensing

Herein, we report aggregation induced red shifted emissions in N,S-doped chiral carbon dots for moisture sensing in common organic solvents and commercial products.

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