Light‐controlled Tyrosine Nitration of Proteins

2021 ◽  
Author(s):  
Tengfang Long ◽  
Lei Liu ◽  
Youqi Tao ◽  
Wanli Zhang ◽  
Jiale Quan ◽  
...  
Keyword(s):  
Tyrosine Nitration

scholarly journals Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid β-peptide-induced cholinergic dysfunction

2003 ◽  
Vol 8 (4) ◽  
pp. 407-412 ◽  
Author(s):  
M H Tran ◽  
K Yamada ◽  
A Nakajima ◽  
M Mizuno ◽  
J He ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Tyrosine Nitration ◽  
Synaptic Protein ◽  
Cholinergic Dysfunction

scholarly journals Vol. 7 (2008) 864–874 Targets of Tyrosine Nitration in Diabetic Rat Retina

2008 ◽  
Vol 7 (6) ◽  
pp. 1188-1189
Author(s):  
Xianquan Zhan ◽  
Yunpeng Du ◽  
John S. Crabb ◽  
Xiaorong Gu ◽  
Timothy S. Kern ◽  
...  
Keyword(s):  
Diabetic Rat ◽  
Tyrosine Nitration ◽  
Rat Retina

scholarly journals Glutamine synthetase as a central element in hepatic glutamine and ammonia metabolism: novel aspects

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Benedikt Frieg ◽  
Boris Görg ◽  
Holger Gohlke ◽  
Dieter Häussinger
Keyword(s):  
Glutamine Synthetase ◽  
Protein Function ◽  
Nitrosative Stress ◽  
Point Mutations ◽  
Central Element ◽  
Ph Sensitive ◽  
Tyrosine Nitration ◽  
Ammonia Metabolism ◽  
Functional Consequences

Abstract Glutamine synthetase (GS) in the liver is expressed in a small perivenous, highly specialized hepatocyte population and is essential for the maintenance of low, non-toxic ammonia levels in the organism. However, GS activity can be impaired by tyrosine nitration of the enzyme in response to oxidative/nitrosative stress in a pH-sensitive way. The underlying molecular mechanism as investigated by combined molecular simulations and in vitro experiments indicates that tyrosine nitration can lead to a fully reversible and pH-sensitive regulation of protein function. This approach was also used to understand the functional consequences of several recently described point mutations of human GS with clinical relevance and to suggest an approach to restore impaired GS activity.

Identification of tyrosine nitration in UCH-L1 and GAPDH

2011 ◽  
Vol 32 (13) ◽  
pp. 1692-1705 ◽  
Author(s):  
Joy D. Guingab-Cagmat ◽  
Stanley M. Stevens ◽  
Mary V. Ratliff ◽  
Zhiqun Zhang ◽  
Mark S. Gold ◽  
...  
Keyword(s):  
Tyrosine Nitration

scholarly journals Protein targets of tyrosine nitration in sunflower (Helianthus annuus L.) hypocotyls

2009 ◽  
Vol 60 (15) ◽  
pp. 4221-4234 ◽  
Author(s):  
Mounira Chaki ◽  
Raquel Valderrama ◽  
Ana M. Fernández-Ocaña ◽  
Alfonso Carreras ◽  
Javier López-Jaramillo ◽  
...  
Keyword(s):  
Helianthus Annuus ◽  
Tyrosine Nitration ◽  
Protein Targets ◽  
Helianthus Annuus L
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