Synthesis, characterization, and drug-release behavior of novel PEGylated bovine serum albumin as a carrier for anticancer agents

2010 ◽  
Vol 119 (5) ◽  
pp. 2635-2643 ◽  
Author(s):  
Soodabeh Davaran ◽  
Davoud Asgari ◽  
Mohammad Reza Rashidi ◽  
Roya Salehi ◽  
Yadolah Omidi
Keyword(s):  
Bovine Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Anticancer Agents ◽  
Bovine Serum ◽  
Release Behavior ◽  
Drug Release Behavior

scholarly journals Nanogels of poly(acrylic acid): Uptake and release behavior with fluorescent oligothiophene-labeled bovine serum albumin

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Simona Argentiere ◽  
Laura Blasi ◽  
Giuseppe Ciccarella ◽  
Giovanna Barbarella ◽  
Roberto Cingolani ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Acrylic Acid ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Acid Uptake ◽  
Release Behavior ◽  
Uptake And Release ◽  
Poly Acrylic Acid

scholarly journals The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release

2021 ◽  
Author(s):  
Tahmineh Atloo ◽  
Ramin Mohammadkhani ◽  
Ali Mohammadi ◽  
Kasra Arbabi Zaboli ◽  
Saeed Kaboli ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Copper Oxide ◽  
Cell Line ◽  
Bovine Serum ◽  
Copper Oxide Nanoparticles ◽  
Buffer Solution ◽  
Biological Environment

Abstract In this work, first, copper oxide nanoparticles (CUO NPs) were synthesized by physical methods and then coated with the bovine serum albumin (BSA) via biologically meditated minerals to form CUO@BSA NPs. Finally, curcumin (CUR) as an anticancer drug were immobilized on the surface of CUO@BSA NPS. The properties of CUO@BSA-CUR NPS were investigated by FTIR, UV-Vis, TEM, and AFM spectroscopes. It was found that the synthesized CUO@BSA-CUR nanoparticles were spherical with a particle size of 20 to 30 nm and have a sustained release of CUR at 37°C in buffer solution. Also, the result of release in biological environment showed that maximum drug release rate for this nanocarrier in pH 7.4 was measured 75% after 48 hours. The cytotoxicity of CUO@BSA-CUR on MDA-MB-231 cell line was studied. The results showed that CUO@BSA-CUR nanoparticles have significant cytotoxic activity on this cell line, while the results of MTT assay indicated the CUO@BSA NPs have no toxicity effect on the cancer cells.

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