Encapsulation of bovine serum albumin within β-cyclodextrin/gelatin-based polymeric hydrogel for controlled protein drug release

IRBM ◽  
2010 ◽  
Vol 31 (4) ◽  
pp. 234-241 ◽  
Author(s):  
A.A. Haroun ◽  
N.R. El-Halawany
Keyword(s):  
Bovine Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Protein Drug ◽  
Polymeric Hydrogel

scholarly journals The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release

2021 ◽  
Author(s):  
Tahmineh Atloo ◽  
Ramin Mohammadkhani ◽  
Ali Mohammadi ◽  
Kasra Arbabi Zaboli ◽  
Saeed Kaboli ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Copper Oxide ◽  
Cell Line ◽  
Bovine Serum ◽  
Copper Oxide Nanoparticles ◽  
Buffer Solution ◽  
Biological Environment

Abstract In this work, first, copper oxide nanoparticles (CUO NPs) were synthesized by physical methods and then coated with the bovine serum albumin (BSA) via biologically meditated minerals to form CUO@BSA NPs. Finally, curcumin (CUR) as an anticancer drug were immobilized on the surface of CUO@BSA NPS. The properties of CUO@BSA-CUR NPS were investigated by FTIR, UV-Vis, TEM, and AFM spectroscopes. It was found that the synthesized CUO@BSA-CUR nanoparticles were spherical with a particle size of 20 to 30 nm and have a sustained release of CUR at 37°C in buffer solution. Also, the result of release in biological environment showed that maximum drug release rate for this nanocarrier in pH 7.4 was measured 75% after 48 hours. The cytotoxicity of CUO@BSA-CUR on MDA-MB-231 cell line was studied. The results showed that CUO@BSA-CUR nanoparticles have significant cytotoxic activity on this cell line, while the results of MTT assay indicated the CUO@BSA NPs have no toxicity effect on the cancer cells.

Folate-targeting and bovine serum albumin-gated mesoporous silica nanoparticles as a redox-responsive carrier for epirubicin release

2019 ◽  
Vol 43 (6) ◽  
pp. 2694-2701 ◽  
Author(s):  
Yuan Zhang ◽  
Yang Xing ◽  
Ming Xian ◽  
Shaomin Shuang ◽  
Chuan Dong
Keyword(s):  
Bovine Serum Albumin ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Serum Albumin ◽  
Cancer Cells ◽  
Bovine Serum ◽  
Mesoporous Silica Nanoparticles ◽  
Redox Responsive ◽  
Folate Targeting ◽  
Triggered Drug Release

A targeted DDS with covalently conjugated BSA and folate for GSH-triggered drug release and recognition of FR-positive cancer cells.

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