CncC/Maf‐mediated xenobiotic response pathway in insects

2020 ◽  
Vol 104 (2) ◽  
Author(s):  
Subba Reddy Palli
Keyword(s):  
Xenobiotic Response

Drosophila Keap1 xenobiotic response factor regulates developmental transcription through binding to chromatin

2021 ◽  
Author(s):  
Jennifer Carlson ◽  
Lindsey Price ◽  
Isabel Cook ◽  
Huai Deng
Keyword(s):  
Response Factor ◽  
Xenobiotic Response

scholarly journals Xenobiotic response element binding enriched in both nuclear and microsomal fractions of rat cerebellum

2003 ◽  
Vol 85 (1) ◽  
pp. 264-273 ◽  
Author(s):  
Nobuyuki Kuramoto ◽  
Katsuhiro Baba ◽  
Keiko Gion ◽  
Chie Sugiyama ◽  
Hideo Taniura ◽  
...  
Keyword(s):  
Response Element ◽  
Rat Cerebellum ◽  
Xenobiotic Response Element ◽  
Xenobiotic Response

scholarly journals The Nuclear Receptor Seven Up Regulates Genes Involved in Immunity and Xenobiotic Response in the Adult Drosophila Female Fat Body

2020 ◽  
Vol 10 (12) ◽  
pp. 4625-4635
Author(s):  
Lesley N. Weaver ◽  
Daniela Drummond-Barbosa
Keyword(s):  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Adult Female ◽  
Fat Body ◽  
Peripheral Tissues ◽  
Immune Genes ◽  
Xenobiotic Detoxification ◽  
Intrinsic Roles ◽  
Xenobiotic Response ◽  
Adult Drosophila

The physiology of organisms depends on inter-organ communication in response to changes in the environment. Nuclear receptors are broadly expressed transcription factors that respond to circulating molecules to control many biological processes, including immunity, detoxification, and reproduction. Although the tissue-intrinsic roles of nuclear receptors in reproduction have been extensively studied, there is increasing evidence that nuclear receptor signaling in peripheral tissues can also influence oogenesis. We previously showed that the Drosophila nuclear receptor Seven up (Svp) is required in the adult fat body to regulate distinct steps of oogenesis; however, the relevant downstream targets of Svp remain unknown. Here, we took an RNA sequencing approach to identify candidate Svp targets specifically in the adult female fat body that might mediate this response. svp knockdown in the adult female fat body significantly downregulated immune genes involved in the first line of pathogen defense, suggesting a role for Svp in stimulating early immunity. In addition, we found that Svp transcriptionally regulates genes involved in each step of the xenobiotic detoxification response. Based on these findings, we propose a testable model in which Svp functions in the adult female fat body to stimulate early defense against pathogens and facilitate detoxification as part of its mechanisms to promote oogenesis.

scholarly journals Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

2004 ◽  
Vol 112 (2) ◽  
pp. 163-169 ◽  
Author(s):  
Michelle M Tabb ◽  
Vladyslav Kholodovych ◽  
Felix Grün ◽  
Changcheng Zhou ◽  
William J Welsh ◽  
...  
Keyword(s):  
Steroid And Xenobiotic Receptor ◽  
Xenobiotic Response ◽  
Xenobiotic Receptor

Suppression ofCYP1A1Transcription by H2O2Is Mediated by Xenobiotic-Response Element

1998 ◽  
Vol 356 (2) ◽  
pp. 142-150 ◽  
Author(s):  
Chuanli Xu ◽  
David S. Pasco
Keyword(s):  
Response Element ◽  
Xenobiotic Response Element ◽  
Xenobiotic Response

Xenobiotic Response in Humanized Double Transgenic Mice Expressing Tetracycline-Controlled Transactivator and Human CYP1B1

2001 ◽  
Vol 395 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Dae Y. Hwang ◽  
Kab R. Chae ◽  
Dong H. Shin ◽  
Jin H. Hwang ◽  
Chae H. Lim ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Double Transgenic Mice ◽  
Xenobiotic Response
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