Drosophila Keap1 xenobiotic response factor regulates developmental transcription through binding to chromatin

Author(s):  
Jennifer Carlson ◽  
Lindsey Price ◽  
Isabel Cook ◽  
Huai Deng
2021 ◽  
pp. 107754632110058
Author(s):  
Qi Zhou ◽  
Liangtao Zhao ◽  
Chong Zheng ◽  
Feng Tu

At present, the wind-induced response analysis of an overhead conductor is mainly based on the action of horizontal normal wind. However, for crossing hillsides or extremely strong winds, such a conductor will bear the action of updraft wind, which will change the geometry of the conductor and make its structural dynamic characteristics nonlinear to some extent. In this work, the in-plane and out-of-plane two-dimensional nonlinear equations were established under the action of self-weight and updraft wind. Furthermore, the improved equations of conductor tension and sag were obtained, and the wind-induced vibration response was further investigated. The results showed that the updraft wind caused the nonlinearity of the tension and sag of the overhead conductor, and the nonlinear geometric change significantly affected its resonance response, which exceeded 25% if the wind speed was 50 m/s. In addition, because the proportion of the resonance response in the total wind-induced response was different, the influence of the wind attack angle calculated using the gust response factor method on the gust response factor was slightly larger than that calculated using the the American society of civil engineers method.


2021 ◽  
Vol 8 (5) ◽  
pp. 58
Author(s):  
Hazel Aberdeen ◽  
Kaela Battles ◽  
Ariana Taylor ◽  
Jeranae Garner-Donald ◽  
Ana Davis-Wilson ◽  
...  

The fastest growing demographic in the U.S. at the present time is those aged 65 years and older. Accompanying advancing age are a myriad of physiological changes in which reserve capacity is diminished and homeostatic control attenuates. One facet of homeostatic control lost with advancing age is glucose tolerance. Nowhere is this more accentuated than in the high proportion of older Americans who are diabetic. Coupled with advancing age, diabetes predisposes affected subjects to the onset and progression of cardiovascular disease (CVD). In the treatment of type 2 diabetes, hypoglycemic episodes are a frequent clinical manifestation, which often result in more severe pathological outcomes compared to those observed in cases of insulin resistance, including premature appearance of biomarkers of senescence. Unfortunately, molecular mechanisms of hypoglycemia remain unclear and the subject of much debate. In this review, the molecular basis of the aging vasculature (endothelium) and how glycemic flux drives the appearance of cardiovascular lesions and injury are discussed. Further, we review the potential role of the serum response factor (SRF) in driving glycemic flux-related cellular signaling through its association with various proteins.


2017 ◽  
Vol 134 ◽  
pp. 33-44 ◽  
Author(s):  
Rambod Abiri ◽  
Noor Azmi Shaharuddin ◽  
Mahmood Maziah ◽  
Zetty Norhana Balia Yusof ◽  
Narges Atabaki ◽  
...  

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