Transvection and long-distance gene regulation

BioEssays ◽  
1990 ◽  
Vol 12 (9) ◽  
pp. 409-414 ◽  
Author(s):  
Vincenzo Pirrotta
Keyword(s):  
Gene Regulation ◽  
Long Distance

scholarly journals Developmental regulators FlbE/D orchestrate the polarity site-to-nucleus dynamics of the fungal bZIP FlbB

2018 ◽  
Author(s):  
Ainara Otamendi ◽  
Elixabet Perez-de-Nanclares-Arregi ◽  
Elixabet Oiartzabal ◽  
Marc S. Cortese ◽  
Eduardo A. Espeso ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Transcription Factors ◽  
Aspergillus Nidulans ◽  
Nuclear Accumulation ◽  
Long Distance ◽  
Developmental Transitions ◽  
Viral Peptide ◽  
Lxxll Motif ◽  
Polarized Cells ◽  
Transduction Mechanisms

AbstractPermanently polarized cells have developed transduction mechanisms linking polarity-sites with gene regulation in the nucleus. In neurons, one mechanism is based on long-distance retrograde migration of transcription factors (TFs).Aspergillus nidulansFlbB is the only known fungal TF shown to migrate retrogradely to nuclei from the polarized region of fungal cells known as hyphae. There, FlbB controls developmental transitions by triggering the production of asexual multicellular structures. FlbB dynamics in hyphae is orchestrated by regulators FlbE and FlbD. At least three FlbE domains are involved in the acropetal transport of FlbB, with a final MyoE/actin filament-dependent step from the subapex to the apex. Experiments employing a T2A viral peptide-containing chimera (FlbE::mRFP::T2A::FlbB::GFP) suggest that apical FlbB/FlbE interaction is inhibited in order to initiate a dynein-dependent FlbB transport to nuclei. FlbD controls the nuclear accumulation of FlbB through a cMyb domain and a C-terminal LxxLL motif. Overall, results elucidate a highly dynamic pattern of FlbB interactions, which enable timely developmental induction. Furthermore, this system establishes a reference for TF-based long-distance signaling in permanently polarized cells.

scholarly journals Efficient studies of long-distance Bmp5 gene regulation using bacterial artificial chromosomes

2000 ◽  
Vol 97 (4) ◽  
pp. 1612-1617 ◽  
Author(s):  
R. J. DiLeone ◽  
G. A. Marcus ◽  
M. D. Johnson ◽  
D. M. Kingsley
Keyword(s):  
Gene Regulation ◽  
Bacterial Artificial Chromosomes ◽  
Long Distance ◽  
Artificial Chromosomes

scholarly journals Interallelic interaction and gene regulation in budding yeast

2016 ◽  
Vol 113 (16) ◽  
pp. 4428-4433 ◽  
Author(s):  
Daoyong Zhang ◽  
Lu Bai
Keyword(s):  
Gene Regulation ◽  
Homologous Chromosome ◽  
Budding Yeast ◽  
The Other ◽  
Delayed Response ◽  
Wild Type ◽  
Long Distance ◽  
Homologous Chromosome Pairing ◽  
Starting Point ◽  
Mutant Promoter

In Drosophila, homologous chromosome pairing leads to “transvection,” in which the enhancer of a gene can regulate the allelic transcription in trans. Interallelic interactions were also observed in vegetative diploid budding yeast, but their functional significance is unknown. Here, we show that a GAL1 reporter can interact with its homologous allele and affect its expression. By ectopically inserting two allelic reporters, one driven by wild-type GAL1 promoter (WT GAL1pr) and the other by a mutant promoter with delayed response to galactose induction, we found that the two reporters physically associate, and the WT GAL1pr triggers synchronized firing of the defective promoter and accelerates its activation without affecting its steady-state expression level. This interaction and the transregulatory effect disappear when the same reporters are located at nonallelic sites. We further demonstrated that the activator Gal4 is essential for the interallelic interaction, and the transregulation requires fully activated WT GAL1pr transcription. The mechanism of this phenomenon was further discussed. Taken together, our data revealed the existence of interallelic gene regulation in yeast, which serves as a starting point for understanding long-distance gene regulation in this genetically tractable system.

Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene Regulation

2000 ◽  
Vol 127 (5) ◽  
pp. 711-715 ◽  
Author(s):  
H. Sasaki ◽  
K. Ishihara ◽  
R. Kato
Keyword(s):  
Dna Methylation ◽  
Gene Regulation ◽  
Long Distance

The Fine Structure of Phloem Cells

1985 ◽  
Vol 43 ◽  
pp. 632-635
Author(s):  
James Cronshaw
Keyword(s):  
Structural Studies ◽  
High Concentration ◽  
Long Distance ◽  
Phloem Tissue ◽  
Sieve Elements ◽  
Long Distance Transport ◽  
P Protein ◽  
Companion Cells ◽  
Electron Microscopical ◽  
Distance Transport

Long distance transport in plants takes place in phloem tissue which has characteristic cells, the sieve elements. At maturity these cells have sieve areas in their end walls with specialized perforations. They are associated with companion cells, parenchyma cells, and in some species, with transfer cells. The protoplast of the functioning sieve element contains a high concentration of sugar, and consequently a high hydrostatic pressure, which makes it extremely difficult to fix mature sieve elements for electron microscopical observation without the formation of surge artifacts. Despite many structural studies which have attempted to prevent surge artifacts, several features of mature sieve elements, such as the distribution of P-protein and the nature of the contents of the sieve area pores, remain controversial.

Anatomy of Gene Regulation

2003 ◽  
Author(s):  
Panagiotis A. Tsonis
Keyword(s):  
Gene Regulation

Popliteal entrapment syndrome and age

VASA ◽  
2012 ◽  
Vol 41 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Schweizer ◽  
Hügli ◽  
Koella ◽  
Jeanneret
Keyword(s):  
Risk Factors ◽  
Leg Pain ◽  
Walking Distance ◽  
Therapeutic Approaches ◽  
Long Distance ◽  
Entrapment Syndrome ◽  
Long Distance Running ◽  
Popliteal Entrapment ◽  
Popliteal Entrapment Syndrome ◽  
Atherosclerotic Risk Factors

On the occasion of diagnosing a popliteal entrapment syndrome in a 59-year old man with no cardiovascular risk factors, who developed acute ischemic leg pain during long distance running, we give an overview on this entity with emphasis on patients’age. The different types of the popliteal artery compression syndrome are summarized. The diagnostic and therapeutic approaches are discussed. The most important clinical sign of a popliteal entrapment syndrome is the lack of atherosclerotic risk factors in patients with limited walking distance. Not only in young athletes but also in patients more than 50 years old the popliteal entrapment syndrome has to be taken into account.

Attachment Styles, Physical Proximity, and Relational Satisfaction

2014 ◽  
Vol 4 (2) ◽  
pp. 106-112
Author(s):  
Anita Shrivastava ◽  
Andrea Burianova
Keyword(s):  
Attachment Styles ◽  
Romantic Relationship ◽  
Distinct Type ◽  
Relational Satisfaction ◽  
Long Distance ◽  
Avoidant Attachment ◽  
Geographic Separation ◽  
Relationship Of ◽  
Attachment Dimensions

This study aimed to explore the relationships between attachment styles, proximity, and relational satisfaction. This was achieved by assessing a distinct type of long distance romantic relationship of flying crews, compared with proximal (non-flying crew) romantic relationships. The responses of 139 expatriate professionals revealed significant associations between proximity and anxious and avoidant attachment dimensions. The role of the avoidant dimension in comparison with that of the anxious dimension was found to be a significant predictor of relational satisfaction. This study contributes significantly toward addressing the role of proximity and attachment in relational satisfaction in a new context of geographic separation.

Sign in / Sign up

Export Citation Format

Share Document