Technologies of carp growing and their features

Carp is one of the few fish farms for which a wide range of technologies has been developed: from extensive, with minimal human intervention in the formation of fish productivity of the reservoir, to intensive, with the most controlled production conditions. Carp has many biological features, enhanced by centuries of breeding work, making this fish extremely “technological”, able to more or less fully realize the genetically determined bioproductive properties of different breeding technologies. Technologies for growing commercial carp according to the level of intensification of the production process can be divided into extensive (grazing), semi-intensive, intensive, and continuous, as a distinct type of intensive technology for growing carp in ponds and pools. Extensive technology assumes that the fish will feed exclusively on natural food, zooplankton, and bottom fauna. In this case, the cost of growing carp will be the lowest; the fish will be called “ecological”, but the growth of individuals will be insignificant. Semi-intensive technology assumes that carp feed on natural feeds, and their energy needs are met by providing carbohydrate additives to feed. Intensive technology believes that carp feeding with compound feeds with high protein content is used, which allows achieving productivity of 3–20 tons/ha. This system requires the highest costs, although it gives the highest performance. The pond must provide additional aeration and water flow to prevent contamination of the reservoir and the development of fish diseases. The main disadvantage of popular carp growing technologies is their staging. All operations are carried out strictly one after another in specialized ponds. Moreover, each stage ends with the descent of the tanks, and the fish are transplanted several times from one to another (from spawning to juvenile, from them to nursery). During this, the carp is injured, which negatively affects its productivity and inevitably leads to waste. To remedy this, fish farming is now using continuous rearing technology. The choice of technology for growing carp is a responsible task on which the profitability of fisheries depends.

An efficient encode-decode deep learning network for lane markings instant segmentation

<span lang="EN-US">Nowadays, advanced driver assistance systems (ADAS) has been incorporated with a distinct type of progressive and essential features. One of the most preliminary and significant features of the ADAS is lane marking detection, which permits the vehicle to keep in a particular road lane itself. It has been detected by utilizing high-specialized, handcrafted features and distinct post-processing approaches lead to less accurate, less efficient, and high computational framework under different environmental conditions. Hence, this research proposed a simple encode-decode deep learning approach under distinguishing environmental effects like different daytime, multiple lanes, different traffic condition, good and medium weather conditions for detecting the lane markings more accurately and efficiently. The proposed model is emphasized on the simple encode-decode Seg-Net framework incorporated with VGG16 architecture that has been trained by using the inequity and cross-entropy losses to obtain more accurate instant segmentation result of lane markings. The framework has been trained and tested on a vast public dataset named Tusimple, which includes around 3.6K training and 2.7 k testing image frames of different environmental conditions. The model has noted the highest accuracy, 96.61%, F1 score 96.34%, precision 98.91%, and recall 93.89%. Also, it has <span>also obtained the lowest 3.125% false positive and 1.259% false-negative value, which transcended some of the previous researches. It is expected to</span> assist significantly in the field of lane markings detection applying deep neural networks.</span>

Believers in pseudoscience present lower evidential criteria

Previous studies have proposed that low evidential criteria or proneness to jump to conclusions influences the formation of paranormal beliefs. We investigated whether the low evidential criteria hypothesis for paranormal beliefs extends to a conceptually distinct type of unwarranted beliefs: those related to pseudoscience. We presented individuals varying in their endorsement of pseudoscientific beliefs with two hypothesis testing tasks. In the beads task, the participants were asked to decide from which of two jars containing different proportions of colored beads they were collecting samples. In the mouse trap task, they were asked to guess which rule determined whether a participant-controlled mouse obtained a piece of cheese or was trapped. In both cases, the volunteers were free to decide when to stop collecting evidence before completing the tasks. Our results indicate that, compared to skeptics, individuals presenting stronger endorsement of pseudoscientific beliefs tend to require less evidence before coming to a conclusion in hypothesis testing situations.

Growth of lithium-indium dendrites in all-solid-state lithium-based batteries with sulfide electrolytes

All-solid-state lithium-based batteries with inorganic solid electrolytes are considered a viable option for electrochemical energy storage applications. However, the application of lithium metal is hindered by issues associated with the growth of mossy and dendritic Li morphologies upon prolonged cell cycling and undesired reactions at the electrode/solid electrolyte interface. In this context, alloy materials such as lithium-indium (Li-In) alloys are widely used at the laboratory scale because of their (electro)chemical stability, although no in-depth investigations on their morphological stability have been reported yet. In this work, we report the growth of Li-In dendritic structures when the alloy material is used in combination with a Li6PS5Cl solid electrolyte and Li(Ni0.6Co0.2Mn0.2)O2 positive electrode active material and cycled at high currents (e.g., 3.8 mA cm−2) and high cathode loading (e.g., 4 mAh cm−2). Via ex situ measurements and simulations, we demonstrate that the irregular growth of Li-In dendrites leads to cell short circuits after room-temperature long-term cycling. Furthermore, the difference between Li and Li-In dendrites is investigated and discussed to demonstrate the distinct type of dendrite morphology.

Computer-Aided Drug Discovery (CADD) Approaches for the Management of Neuropathic Pain

: Neuropathic pain occurs due to physical damage, injury, or dysfunction of neuronal fibers. The pathophysiology of neuropathic pain is too complex. Therefore, an accurate and reliable prediction of the appropriate hits/ligands for the treatment of neuropathic pain is a challenging process. However, computer-aided drug discovery approaches contributed significantly to discovering newer hits/ligands for the treatment of neuropathic pain. The computational approaches like homology modeling, induced-fit molecular docking, structure-activity relationships, metadynamics, and virtual screening were cited in the literature for the identification of potential hit molecules against neuropathic pain. These hit molecules act as inducible nitric oxide synthase inhibitors, FLAT antagonists, TRPA1 modulators, voltage-gated sodium channel binder, cannabinoid receptor-2 agonists, sigma-1 receptor antagonists, etc. Sigma-1 receptor is a distinct type of opioid receptor and several patents were obtained for sigma-1 receptor antagonists for the treatment of neuropathic pain. These molecules were found to have a profound role in the management of neuropathic pain. The present review describes the validated therapeutic targets, potential chemical scaffolds, and crucial protein-ligand interactions for the management of neuropathic pain based on the recently reported computational methodologies of the present and past decades. The study can help the researcher to discover newer drugs/drug-like molecules against neuropathic pain.

Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance

Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had distinct impacts on cancer progression, either promoting or inhibiting cancer cell growth. Mesenchymal stem cells (MSCs) are a distinct type of cells that is linked to tumor development. MSCs are recognized for homing to tumor locations and promoting or inhibiting cancer cell proliferation, angiogenesis and metastasis. Moreover, emerging studies suggests that MSCs are also involved in therapeutic resistance. In this review, we analyzed the existing researches and elaborate on the functions of MSCs in cancer progression and anticancer therapeutic resistance, demonstrating that MSCs may be a viable cancer therapeutic target.

PATH-23. OLIGOSARCOMA, IDH-MUTANT IS A DISTINCT AGGRESSIVE TYPE

Oligodendrogliomas are defined by IDH-mutations and the co-deletion of chromosomal arms 1p and 19q. In the past, case reports and small series described gliomas with sarcomatous features arising from oligodendrogliomas, so called oligosarcomas. Here, we report a group of 23 IDH-mutant oligosarcomas that form a distinct methylation group. The tumors were recurrences from prior oligodendrogliomas or developed de novo. Precursor tumors of 11 oligosarcomas were histologically and molecularly indistinguishable from conventional oligodendrogliomas. Tumor cells were embedded in a reticulin fibers network in all oligosarcomas, frequently showing p53 accumulation, positivity for SMA, and regain of H3K27me3 as compared to primary lesions. In 5 oligosarcomas no 1p/19q co-deletion was detectable, even though it was present in the primary lesions. Oligosarcomas harbored an increased chromosomal copy number variation load with frequent CDKN2A/B deletions. Proteomic profiling demonstrated oligosarcomas to be highly distinct from conventional grade 3 oligodendrogliomas with consistent evidence for smooth muscle differentiation. Expression of several tumor suppressors including NF1 and STAG2 was lost whereas oncogenic YAP1 was aberrantly overexpressed in oligosarcomas. Panel sequencing revealed mutations in TP53 and NF1 along with IDH1/2 and TERT promoter mutations. Survival of patients was significantly poorer for oligosarcomas as for grade 3 oligodendrogliomas but comparable to grade 4 IDH-mutant astrocytomas. These results establish oligosarcoma as a distinct type of IDH-mutant glioma differing from conventional oligodendrogliomas on the histologic, epigenetic, proteomic, molecular and clinical level. Diagnosis can be based on the characteristic DNA methylation profile or the combined evidence of sarcomatous histology, IDH-mutation and TERT promoter mutation with or without 1p/19q co-deletion.

Downregulated Ferroptosis-Related Gene STEAP3 as a Novel Diagnostic and Prognostic Target for Hepatocellular Carcinoma and Its Roles in Immune Regulation

Ferroptosis, a distinct type of regulated cell death, has been reported to be involved in the tumorigenesis of liver hepatocellular carcinoma (LIHC). However, the precise functions and potential mechanisms of ferroptosis in LIHC were still poorly understood. Herein, we investigated the biological roles of ferroptosis-related gene STEAP3 in LIHC. STEAP3 was previously proved to serve a key regulator in ferroptosis via mediating the iron metabolism. Comprehensive bioinformatics from several databases revealed that STEAP3 was significantly downregulated in LIHC tissues and exhibited the favorable prognostic significance in LIHC patients. The downregulated STEAP3 was further confirmed in two LIHC cells Huh7 and MHCC97H using real-time PCR and western blot. And STEAP3 overexpression significantly inhibited the cell proliferation in Huh7 and MHCC97H cells. In addition, clinical data identified the relationship between STEAP3 expression and several clinicopathological parameters of LIHC patients, including histologic grade, alpha fetal protein (AFP) concentration, etc. Receiver operation characteristic (ROC) curve revealed STEAP3 as a potential diagnostic biomarker for LIHC patients. Moreover, the co-expression network of STEAP3 was explored to gain a better insight into its underlying signaling pathways. Finally, aberrant STEAP3 might participate in varieties of immune-associated signatures in LIHC pathogenesis, including immunostimulators, immunoinhibitors, chemokines, and chemokine receptors. Taken together, these findings could enhance our knowledge regarding the inhibitory roles and underlying biological significance of STEAP3 in LIHC tumorigenesis.

Observation of a Floquet symmetry-protected topological phase with superconducting qubits

Quantum many-body systems away from equilibrium host a rich variety of exotic phenomena that are forbidden by equilibrium thermodynamics. A prominent example is that of discrete time crystals [1-8], where time translational symmetry is spontaneously broken in periodically driven systems. Pioneering experiments have observed signatures of time crystalline phases with trapped ions [9,10], spins in nitrogen-vacancy centers [11-13], ultracold atoms [14,15], solid spin ensembles [16,17], and superconducting qubits [18-20]. Here, we report the observation of a distinct type of intrinsically non-equilibrium state of matter, a Floquet symmetry-protected topological phase, which is implemented through digital quantum simulation with an array of programmable superconducting qubits. Unlike the discrete time crystals reported in previous experiments, where spontaneous breaking of the discrete time translational symmetry occurs for local observables throughout the whole system, the Floquet symmetry-protected topological phase observed in our experiment breaks the time translational symmetry only at the boundaries and has trivial dynamics in the bulk. More concretely, we observe robust long-lived temporal correlations and sub-harmonic temporal response for the edge spins over up to 40 driving cycles using a circuit whose depth exceeds 240. We demonstrate that the sub-harmonic response is independent of whether the initial states are random product states or symmetry-protected topological states, and experimentally map out the phase boundary between the time crystalline and thermal phases. Our work paves the way to exploring novel non-equilibrium phases of matter emerging from the interplay between topology and localization as well as periodic driving, with current noisy intermediate-scale quantum processors [21].

Perceptions, reality and semantics: exploring perceptions of coaching and academic advising as distinct roles

PurposeCoaching in higher education has become increasingly common across the United States. Our qualitative study explores the perceptions of coaches and advisors, as they consider academic coaching as a role distinct from academic advising.Design/methodology/approachOur study adopts a qualitative research approach. Two focus groups were conducted with 14 coaching and academic advising professionals.FindingsOur findings identify at least three major themes when considering academic coaching as a role distinct from academic advising: (1) Potential role overlap, (2) Caseload disparities and (3) Philosophical differences. The indiscriminate use of the title of “coach” contributed to confusion, ambiguity and tension.Practical implicationsWithout a clear understanding of the coach role as a distinct type of support in higher education, confusion and ambiguity are likely to continue.Originality/valueNo studies have explored the perceptions of coaches and advisors, as they consider academic coaching as a role distinct in the United States.