The utilize of complex arrangement approach for spectroscopic examination of a some cephalosporins with Eosin Y in their pure forms, pharmaceutical dosage forms and human plasma

Luminescence ◽  
2021 ◽  
Author(s):  
Hesham Salem ◽  
Mahmoud A. Omar ◽  
Dina Z. Mazen ◽  
Deena A. M. Nour El‐Deen
Keyword(s):  
Human Plasma ◽  
Dosage Forms ◽  
Eosin Y ◽  
Pharmaceutical Dosage Forms ◽  
Spectroscopic Examination ◽  
Complex Arrangement

scholarly journals Development and validation of a new spectrofluorimetric method for the determination of some beta-blockers through fluorescence quenching of eosin Y. Application to content uniformity test

2016 ◽  
Vol 14 (1) ◽  
pp. 258-266 ◽  
Author(s):  
Sayed M Derayea ◽  
Mahmoud A Omar ◽  
Mohamed Aboel-Kasem Abdel-Lateef ◽  
Ahmed I. Hassan
Keyword(s):  
Fluorescence Quenching ◽  
Beta Blockers ◽  
Dosage Forms ◽  
Ion Pair ◽  
Content Uniformity ◽  
Eosin Y ◽  
Pharmaceutical Dosage Forms ◽  
Quenching Effect ◽  
Spectrofluorimetric Method

AbstractA simple, rapid, sensitive and economic spectrofluorimetric method has been developed and validated for determination of some β-adrenergic blocking agents namely; betaxolol hydrochloride (BTX), carvedilol (CAR), labetalol hydrochloride (LBT), nebivolol hydrochloride (NEB) and propranolol hydrochloride (PRO). The method is based on the quenching effect of the cited drugs on the fluorescence intensity of eosin Y at pH 3.4 (acetate buffer). The fluorescence quenching is due to the formation of an ion-pair complex and was measured without extraction at 545 nm (λex. 301.5 nm). The factors affecting the formation of the ion-pair complex were carefully studied and optimized. Under the optimal conditions, the linear ranges for the relationship between the fluorescence quenching value and the concentration of the investigated drugs were 100-2500, 150-2500 and 50-2250 ng mL-1 for (BTX, CAR), (LBT, NEB) and (PRO) respectively. The method was validated according to ICH guidelines and was applied for determination of the cited drugs in pharmaceutical dosage forms with excellent recoveries. In addition, content uniformity testing of some commercial dosage forms was checked by the proposed method.

scholarly journals Core–shell particles and monolithic columns; tools for simultaneous LC analysis of avanafil, sildenafil, apomorphine, trazodone, yohimbine, tramadol and dapoxetine in pharmaceutical dosage forms, counterfeit products and human plasma

RSC Advances ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 1379-1387 ◽  
Author(s):  
Adel Ehab Ibrahim ◽  
Hisham Hashem ◽  
Magda Elhenawee ◽  
Hanaa Saleh
Keyword(s):  
Human Plasma ◽  
Dosage Forms ◽  
Sexual Disorders ◽  
Monolithic Columns ◽  
Core Shell ◽  
Pharmaceutical Dosage Forms ◽  
Shell Particles ◽  
Counterfeit Products

By 2025, it's estimated that 322 million males worldwide will suffer from sexual disorders. This study provides two simple green tools for analysis of some male sexual enhancers using HPLC on core–shell particles and monolithic RP-columns.

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