Porous Organic Cage for enantiomeric fluorescence recognition of amino acid and hydroxy acid

Luminescence ◽  
2021 ◽  
Author(s):  
Yang Liu ◽  
Jia Jia ◽  
Tong Liao ◽  
Jin Luo ◽  
Xinfeng Zhang
Keyword(s):  
Amino Acid ◽  
Hydroxy Acid

ChemInform Abstract: HETEROCYCLES OF GERMANIUM, PHOSPHORUS(III), ARSENIC(III) AND SULFUR HAVING AMINO ACID OR HYDROXY ACID LIGANDS

1978 ◽  
Vol 9 (4) ◽  
Author(s):  
H. LAVAYSSIERE ◽  
G. DOUSSE ◽  
J. SATGE
Keyword(s):  
Amino Acid ◽  
Hydroxy Acid

scholarly journals Studies on the Utilization of the α-Hydroxy Acid of Methionine by Chicks Fed Crystalline Amino Acid Diets

1974 ◽  
Vol 53 (2) ◽  
pp. 680-686 ◽  
Author(s):  
W.R. Featherston ◽  
G.W. Horn
Keyword(s):  
Amino Acid ◽  
Hydroxy Acid

scholarly journals Absolute Stereochemistry of the β-Hydroxy Acid Unit in Hantupeptins and Trungapeptins

2016 ◽  
Vol 11 (1) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Deepak Kumar Gupta ◽  
Gary Chi Ying Ding ◽  
Yong Chua Teo ◽  
Lik Tong Tan
Keyword(s):  
Amino Acid ◽  
Structural Feature ◽  
Absolute Configuration ◽  
Hydroxy Acid ◽  
Hplc Analysis ◽  
The Absolute ◽  
Absolute Stereochemistry ◽  
Common Structural Feature ◽  
Acid Unit

The β-hydroxy/amino acid unit is a common structural feature of many bioactive marine cyanobacterial depsipeptides. In this study, the absolute stereochemistry of the β-hydroxy acid moieties in hantupeptins and trungapeptins were determined through their synthesis and HPLC analysis of the Mosher ester derivatives. Synthesis of two3-hydroxy-2-methyloctanoic acid (Hmoa) stereoisomers, (2 S,3 R)-Hmoa and (2 S,3 S)-Hmoa, were achieved using diastereoselective asymmetric method and the retention times of all four Hmoa isomers were established indirectly by RPLC-MS analysis of their Mosher ester derivative standards. Based on the retention times of the standards, the absolute configuration of the Hmoa unit in hantupeptin C (3) and trungapeptin C (6) was assigned as (2 R,3 S)- and (2 S,3 R)-Hmoa, respectively. The use of the Mosher's reagents, coupled with HPLC analysis, provided a viable alternative to the absolute stereochemical determination of β-hydroxy acid units in depsipeptides.

Inhibition of Amyloid Fibril Formation of Human Amylin by N-Alkylated Amino Acid and -Hydroxy Acid Residue Containing Peptides

2002 ◽  
Vol 8 (18) ◽  
pp. 4285-4291 ◽  
Author(s):  
Dirk T. S. Rijkers ◽  
Jo W. M. Höppener ◽  
George Posthuma ◽  
Cornelis J. M. Lips ◽  
Rob M. J. Liskamp
Keyword(s):  
Amino Acid ◽  
Hydroxy Acid ◽  
Amyloid Fibril ◽  
Fibril Formation ◽  
Amyloid Fibril Formation ◽  
Human Amylin

scholarly journals l-Selective Amidase with Extremely Broad Substrate Specificity from Ochrobactrum anthropi NCIMB 40321

2005 ◽  
Vol 71 (12) ◽  
pp. 7961-7973 ◽  
Author(s):  
Theo Sonke ◽  
Sandra Ernste ◽  
Renate F. Tandler ◽  
Bernard Kaptein ◽  
Wilco P. H. Peeters ◽  
...  
Keyword(s):  
Amino Acid ◽  
Hydroxy Acid ◽  
Reverse Genetics ◽  
Ochrobactrum Anthropi ◽  
Initial Activity ◽  
Wild Type ◽  
Cysteine Protease Inhibitors ◽  
Gene Encoding ◽  
Calculated Molecular Weight ◽  
Chelating Compounds

ABSTRACT An industrially attractive l-specific amidase was purified to homogeneity from Ochrobactrum anthropi NCIMB 40321 wild-type cells. The purified amidase displayed maximum initial activity between pH 6 and 8.5 and was fully stable for at least 1 h up to 60°C. The purified enzyme was strongly inhibited by the metal-chelating compounds EDTA and 1,10-phenanthroline. The activity of the EDTA-treated enzyme could be restored by the addition of Zn2+ (to 80%), Mn2+ (to 400%), and Mg2+ (to 560%). Serine and cysteine protease inhibitors did not influence the purified amidase. This enzyme displayed activity toward a broad range of substrates consisting of α-hydrogen- and (bulky) α,α-disubstituted α-amino acid amides, α-hydroxy acid amides, and α-N-hydroxyamino acid amides. In all cases, only the l-enantiomer was hydrolyzed, resulting in E values of more than 150. Simple aliphatic amides, β-amino and β-hydroxy acid amides, and dipeptides were not converted. The gene encoding this l-amidase was cloned via reverse genetics. It encodes a polypeptide of 314 amino acids with a calculated molecular weight of 33,870. Since the native enzyme has a molecular mass of about 66 kDa, it most likely has a homodimeric structure. The deduced amino acid sequence showed homology to a few other stereoselective amidases and the acetamidase/formamidase family of proteins (Pfam FmdA_AmdA). Subcloning of the gene in expression vector pTrc99A enabled efficient heterologous expression in Escherichia coli. Altogether, this amidase has a unique set of properties for application in the fine-chemicals industry.

ChemInform Abstract: Synthesis of 2-Hydroxy Acid from 2-Amino Acid by Clostridium butyricum.

ChemInform ◽  
2010 ◽  
Vol 30 (12) ◽  
pp. no-no
Author(s):  
Nasser Khelifa ◽  
Marie-Jose Butel ◽  
Alain Rimbault
Keyword(s):  
Amino Acid ◽  
Hydroxy Acid ◽  
Clostridium Butyricum

scholarly journals Synthesis of α-Hydroxyisovaleric acid (Hiv) and α-Acetyloxyisovaleric Acid (Ac-Hiv), Precursors of Aureobasidin B, with Improved Yield

2018 ◽  
Vol 6 (3) ◽  
pp. 116
Author(s):  
Rani Maharani ◽  
Andi Rahim ◽  
Herdanu Rizqullah ◽  
Nur Muhammad Miftah ◽  
Ace Tatang Hidayat ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Sulfuric Acid ◽  
Amino Acid ◽  
Sodium Nitrite ◽  
Good Yield ◽  
Hydroxy Acid

α-Hydroxyisovaleric acid (Ac-Hiv) and α-acetyloxyisovaleric acid (Ac-Hiv) have been successfully synthesized through a diazotisation of amino acid using sodium nitrite with the catalyst of sulfuric acid and acetic acid, respectively. In the synthesis of Hiv, Zubia et al. (2005) mentioned that 3 equivalents of sodium nitrite for the reaction gave the hydroxy acid with a good yield. However, Cohen-Arazi et al. (2008) described that 6 equivalents of sodium nitrite resulted the highest yield. In present study, a variation of equivalents of sodium nitrite (3, 4, 5, 6 eq.) were trialed for the same method of synthesis. Through several experiments, we found that 6 equivalents of sodium nitrite were the best portion among all. This finding was applied into the synthesis of protected Hiv (Ac-Hiv) that was previously reported by Maharani et al. (2017) giving 63% yield when 3 equivalent of sodium nitrite was employed. By increasing the equivalent of sodium nitrite into 6 equivalents, the Ac-Hiv can be synthesized with an improved yield (71%).

scholarly journals β-C(sp3)–H Arylation of α-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group

2015 ◽  
Vol 17 (24) ◽  
pp. 5966-5969 ◽  
Author(s):  
Tetsuya Toba ◽  
Yi Hu ◽  
Anh T. Tran ◽  
Jin-Quan Yu
Keyword(s):  
Amino Acid ◽  
Hydroxy Acid ◽  
Directing Group

scholarly journals Enzymatic Degradation of Sequential Polymers Containing a Tripeptide Sequence L-Alanine–L-Leucine–γ-Ethyl L-Glutamate and an α-Hydroxy Acid L-Lactic Acid or α-Amino Acid L-Alanine

1988 ◽  
Vol 20 (3) ◽  
pp. 281-284 ◽  
Author(s):  
Masaharu Asano ◽  
Masaru Yoshida ◽  
Isao Kaetsu ◽  
Ryoichi Katakai ◽  
Tooru Mashimo ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Amino Acid ◽  
Hydroxy Acid ◽  
Enzymatic Degradation
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