Cellular pharmacokinetics and pharmacodynamics mechanisms of ginkgo diterpene lactone and its modulation of P‐glycoprotein expression in human SH‐SY5Y cells

2019 ◽  
Vol 33 (12) ◽  
Author(s):  
Jing‐ying Liu ◽  
Ting Geng ◽  
Kun Duan ◽  
Xia Gao ◽  
Chao‐jie Huang ◽  
...  
Keyword(s):  
Pharmacokinetics And Pharmacodynamics ◽  
Cellular Pharmacokinetics ◽  
P Glycoprotein

scholarly journals Competitive Substrates for P-Glycoprotein and Organic Anion Protein Transporters Differentially Reduce Blood Organ Transport of Fentanyl and Loperamide: Pharmacokinetics and Pharmacodynamics in Sprague-Dawley Rats

2009 ◽  
Vol 108 (1) ◽  
pp. 149-159 ◽  
Author(s):  
Iman A. Elkiweri ◽  
Yan Ling Zhang ◽  
Uwe Christians ◽  
Ka-Yun Ng ◽  
Martha C. Tissot van Patot ◽  
...  
Keyword(s):  
Organic Anion ◽  
Sprague Dawley ◽  
Pharmacokinetics And Pharmacodynamics ◽  
P Glycoprotein ◽  
Sprague Dawley Rats ◽  
Protein Transporters

Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: In vivo evidence of involvement of P-glycoprotein in risperidone disposition

2005 ◽  
Vol 78 (1) ◽  
pp. 43-51 ◽  
Author(s):  
T NAKAGAMI ◽  
N YASUIFURUKORI ◽  
M SAITO ◽  
T TATEISHI ◽  
S KANEO
Keyword(s):  
Pharmacokinetics And Pharmacodynamics ◽  
P Glycoprotein

scholarly journals New antimalarial 3-methoxy-1,2-dioxanes: optimization of cellular pharmacokinetics and pharmacodynamics properties by incorporation of amino and N-heterocyclic moieties at C4

RSC Advances ◽  
2015 ◽  
Vol 5 (89) ◽  
pp. 72995-73010 ◽  
Author(s):  
D. P. Sonawane ◽  
M. Persico ◽  
Y. Corbett ◽  
G. Chianese ◽  
A. Di Dato ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Cellular Pharmacokinetics

A new series of 3-methoxy-1,2-dioxanes containing an amino moiety at C4 was synthesized, displaying nanomolar antimalarial activity without being cytotoxic.

scholarly journals Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes

2013 ◽  
Vol 9 (4) ◽  
pp. 504-513 ◽  
Author(s):  
Chenguang Zhou ◽  
Yue Zhang ◽  
Bo Yu ◽  
Mitch A. Phelps ◽  
L. James Lee ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Cationic Liposomes ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Cellular Pharmacokinetics

scholarly journals Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0172628 ◽  
Author(s):  
Narasimha M. Midde ◽  
Namita Sinha ◽  
Pradeep B. Lukka ◽  
Bernd Meibohm ◽  
Santosh Kumar
Keyword(s):  
Ethanol Exposure ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Cellular Pharmacokinetics ◽  
Hiv 1

scholarly journals Multidrug resistance gene (MDR1) - marker of therapeutic resistance and severity of disease

2009 ◽  
Vol 7 (3) ◽  
pp. 9-13
Author(s):  
Z A Mironova ◽  
V I Trofimov ◽  
M A Simakova ◽  
E D Iantchina ◽  
M V Dubina
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Therapeutic Resistance ◽  
Inadequate Response ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Multidrug Resistance Gene ◽  
Severity Of Disease ◽  
P Glycoprotein ◽  
Genes Expression

Genes polymorphism is known to be one of the causes of the inadequate response to drugs or drugs resistance. In the most of cases drugs influence depends on interaction of several products of genes expression, which influence on drugs pharmacokinetics and pharmacodynamics. Present article concerns the review of publications and results of original investigations concerning the multidrug resistance gene (MDRl) expression associations with P-glycoprotein-170 (Pgp-170) expression in different diseases and the role of Pgp-170 in distribution of drugs in tissues.

Cellular pharmacokinetics and pharmacodynamics of dipyridamole in vascular smooth muscle cells

2006 ◽  
Vol 72 (8) ◽  
pp. 956-964 ◽  
Author(s):  
Weiwei Zhu ◽  
Takahisa Masaki ◽  
Alfred K. Cheung ◽  
Steven E. Kern
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Cellular Pharmacokinetics
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